Chapter 1. Cell Injury - Intracellular Accumulations

Question 1

how does fatty change in the liver come about?

Answer 1

cytosolic accumulation of TG, usually packaged in VLDL fraction

• increased TG synthesis occurs with increased conversion of DHAP to G3P, then adding 3 FA
• -increased NADH production from alcohol increases conversion
• increased CHO intake increases DHAP
• decreased packaging of TG into VLDL and secretion of VLDL into plasm aby apo B-100

Question 2

what is the morophology of fatty liver?

Answer 2

normal or enlarged liver with yellowish discoloration

• clear space pushing nucleus to periphery
• fatty change may also occur in cardiac muscle from severe anemia, diphtheria (exotoxin inhibits beta-oxidation of FA) to give mottled appearance (“tabby cat or thrush heart”)

Question 3

what is dystrophic calcification?

Answer 3

calcification of necrotic tissue, with normal serum calcium and phosphate

Question 4

what is metastatic calcification?

Answer 4

calcification of normal tissue, due to increased serum calcium and/or phosphate