Chapter 1, 2, and 3 Flashcards
What is a natural nonspecific immune response?
External barriers and inflammation
What are all of the external barriers?
Skin, mucus, bodily fluid secretion, friendly bacteria
Skin
- Barrier against most pathogens
- Prevents bacteria from surviving due to lactic acid & fatty acids in sweat and low pH generated by sebaceous secretion’s
Mucus
- keeps bacteria from attaching to surface of the body
- Cilia (hair-like projections that move stuff from around) remove trapped foreign particles
Bodily fluid secretion
Tears, cerumen (earwax), urine removes bacteria and foreign particles for the body (high pH removes/kill bacteria in the vagina/urethra)
Tears gastric juice, semen, nasal secretion and saliva contain bactericidal components that destroy pathogens
Friendly bacteria
Bacteria in vaginal produce lactic acid and metabolic glycogen secreted by b=vaginal epithelium. Friendly bacteria are killed antibiotic use glycogen increases and allows yeast to grow, producing vaginal candidiasis (yeast infection)
Cause of inflammation is..,.
injury, infection, hypersensitivity
Steps of inflammation
- Injury /infection/ hypersensitivity
- constriction of blood vessels
- dilation of blood vessels
permeability increases (allows WBC to leave) - Leukocytes (WBC) leaves blood vessel to fight off bacteria
- phagocytosis
- WBC travel toward the site of injury through chemotaxis
diapedesis
leukocytes leave blood vessel to go fight of bacteria that have been exposed due to trauma
Process of Chemotaxis
Trauma skin realses histamine which attracts WBS
Like everyone gathering to the kitchen during Thanksgiving dinner
Mediators
lure leukocytes to the inflammation site
Ex. histamine, others
Chain of Infection
Pathogen, Reservoir, Portal of exit, Mode of Transmittion, Portal of entry, new host
Pathogen
disease causing agent normally lives and grows (ex. virus, bacteria, rickettsia, protozoa, etc.)
Reservoir
habitat in which an infectous agent normally lives and grows
Ex. humans, animal, environmental (plants soil, water)
Portal of exit
path by which an agent leaves the source host
Modes of Transmittion
how pathogens are passed
Direct transmittion
direct contact, droplet spread, skin/mucous membrane, kissing sexual intercourse
Did these two people touch? Have to be yes
indirect transmittion
airborne, vehicle born, vector borne (mechanical/biological)
Touching or ingesting any contaminated object or food.
no one touched by anyone
Portal of entry
agent enters susceptible host through (respiratory, oral, skin, intravenous, gastrointestinal)
New host
final link is a susceptible host
Infection
invasion and multiplication of pathogenic or disease-producing microorganisms
Fungi
present in soil air water. Thrive in warm dark moist environement
Rickettsia
Bacteria-like organisms transmitted through bites of fleas, lice, ticks mosquitoes, and mites
Parasites
Protozoa and Metazoa
Protozoa
Microscopic single celled parasitic animals
release toxins/enzymes that destroy cells or interfere with function
Metazoa
Multi-cellular parasitic animals (worms)
Tapeworm, roundworms, flukes
Lodge in various body parts - compete for the body’s food
Viruses
Smallest disease causing agents seen with e microscope
Borrow cell’s machinery to reproduce and burst out of cell or may stay in cell to synthesize new viruses w/out disturbing the cell
May coexist indefinitely in human peacefully
Outside factors may active virus leading to presence of actual disease
Humoral immunity
B lymphocytes (b-cells) produce antibodies that protect against parasites such as bacteria and viruses
Cell-mediated immunity
T-cells produce lymphokines which protect against bacteria viruses and tumors
Active natural immunity
exposure, body produces antibodies
active artificial immunity
vaccination, triggers the immune system
passive natural immunity
mother to baby (placenta and breast milk)
Passive artificial immunity
inoculation with antibodies (donation of plasma, fecal matter transplant)
Allergy
immune system can become overactive or misdirected
Hypersensitivity
- Immune identifies harmless subs as potentially harmful
- Intro into body by different routes
- Sx range from a mild rash to life threating antiphallic shock
- Most allergy attacks acute and not recurrent
- Most common is allergic
Urticaria
Rounds, transient, elevations of the skin (wheals) surrounded by redness
Anaphylaxis
potentially life threatening reaction to an antigen
Pruritus
severe itching
erythema
redness of the skin
edema
soft tissue swelling
stridor
high pitched sound during respiration
dyspnea
labored or difficult breathing
Autoimmunity
inappropriate immune response
excessive T cell and B cell attacks
Ex. Lupus, Rheumatoid Arthritis, Hashimoto
Immunodeficiency
B cell or T cell deficiency
AIDS
Hodgkin lymphoma
Conventional Medicine
Came about with Pasteur and Germ Theory
Find the problem and fix the problem
MD, PA, RN
Integrative Medicine
theory that there is a balance and harmony between the body, mind, and spirit
illness linked an imbalanced of these factors
Treat entire person
Acute pain
sudden onset of pain, may last hours, days weeks or months normal expected time of duration
Chronic pain
pain that continues beyond normal expected time for resolution, pain that lasts longer than normal time frame
Chronic pain depends on condition
P-place
point of the pain
A amount
quantify the pain on a scale of 1-10
I interactions
what worsens the pain
N neutralizers
What lessens the pain