Chapter 1-2

Question 1

What are the 3 “Rs”

Answer 1

Refinement, Reduction, Replacement

Question 2

What are laboratory animals or “animals” according to the Guide?

Answer 2

vertebrate animals produced for or used for research, testing and teaching

Question 3

The Guide endorses what government principles

Answer 3

The US Government Principles for Utilization and Care of Vertebrate animals used in Testing Research and Training (IRAC 1985)

Question 4

How does an engineering standard differ from a performance standard

Answer 4

Engineering standards are prescriptive with minimal flexibility. Performance stands allows flexibility to get to the final desired outcome

Question 5

What is a practice standard?

Answer 5

applies profession judgement, peer-reviewed publications, experience etc to get to the desired outcome and improved animal care and use

Question 6

How should a “must” be interpreted in the Guide

Answer 6

it is imperative or mandatory

Question 7

How are “should” and “may” interpreted in the Guide

Answer 7

Should-Strong recommendation

May- suggestion to be considered

Question 8

What 3 elements should compose the “program management”, and work together as a collaboration

Answer 8

IO, AV, IACUC

Question 9

Which entity of the program management bears the ultimate responsibility

Answer 9

IO- should be the one able to provide resources

Question 10

What is the general responsibility of the AV

Answer 10

health and well being of all animals used at the institutioo

Question 11

T or F. All program personnel training should be documented

Answer 11

T

Question 12

Each institution should or must establish and occupation Health and safety program

Answer 12

MUST

Question 13

Is it ok to wear outer garments that have been in an animal room outside of the animal facility

Answer 13

No, not unless they are covered

Question 14

T or F. Personnel should be evaluated for physical and psychological ability to use respiratory protection

Answer 14

T

Question 15

Tor F. The employee should be able to furnish appropriate PPE and suitable attire for working in hazardous environment (such as with animals or other chemical or bio hazards) prior to being hired?

Answer 15

F

The institution should require this for personnel, as often as necessary

Question 16

According to the Guide, who, at a minimum, should make up the IACUC

Answer 16

• a veterinarian with appropriate training and experience
• a scientist working with animals
• a non scientist, from within or out of the institution
• a public member

Question 17

T or F. The public member of IACUC is allowed to be compensated for participation

Answer 17

T. As long as it is not to an amount that would compromise the members representation of the public at large

Question 18

How many voting members on the IACUC can be from the same administrative unit within the institution?

Answer 18

Not more than 3

same as USDA

Question 19

According to the Guide how often must program review and facilities inspection by the IACUC occur

Answer 19

At least annually, but more often as necessary

USDA says semi annually- every 6 mo)

Question 20

What is the general definition of experimental endpoint?

Answer 20

when the scientific aims and objectives have been met

Question 21

What is the general definition of the human endpoint.

Answer 21

When an animal pain or distress is prevented terminated or relieved.

Question 22

Ideally, when shoud humane endpoints be defined?

Answer 22

Prior to start of study, and detailed in the protocol

Question 23

According to the Guide, in what 3 circumstances are multiple major surgeries acceptable

Answer 23

• on the same protocol and essential to scientific aim
• scientifically justified
• necessary for clinical care

Question 24

When is is necessary for the IO to submit a request to USDA/APHIS to allow a regulated animal to undergo mulitple major surgeries

Answer 24

-when the request is to perform surgery on the same animal in separate unrelated protocols

Question 25

T or F. Cost savings and animal sparing are acceptable reasons for performing multiple major survival surgery

Answer 25

F.

These can be considered in rare situations, but generally should be discouraged

Question 26

How often should animals on a food or fluid regulation protocol be weighed.

Answer 26

At least weekly, more often for those requiring greater restriction

Question 27

Who should approve the use of non-pharmaceutical grade products

Answer 27

must be justified and approved by IACUC

Question 28

T or F. The Guide is applicable to agricultural animals used in biomedical reasearch

Answer 28

T. For those being used in farm research The Guide for Care and use of Agricultural animals used in research and teaching may be applicable