Chap 6-Med Tx Of PD

Question 1

DA with 5-HT activity

Answer 1

Lisuride

*liSHUride

Question 2

Longest acting DA

Answer 2

CaberGOLiNe

Question 3

Most important DA for preventing or reducing “wearing off” bec. Of its t1/2

Answer 3

Cabergoline

Question 4

DA with anti-tremor effect

Answer 4

Piribedil

*Remember enchong’s tremulous peri peri chicken dance

Question 5

Weakest DA clinically

Answer 5

Bromocriptine

*Bromo promo

Question 6

DAs with D1 activity

Answer 6

Lisuride, Apomorphine, Pergolide

*1 LAP

Question 7

Dopamine receptor impt. For anti-PD effect

Answer 7

D2

Question 8

T/F. It is unknown how D3 is important for anti-PD effects

Answer 8

True

Question 9

Dopamine receptor implicated in ICD

Answer 9

D3

Question 10

Side effects of DA

Answer 10

Sleep attacks, drowsiness, confusion 
OH 
Nausea 
Edema 
ICD

Question 11

DA for rescue in OFF states

Answer 11

Apomorphine

Question 12

Important pre-treatment before using apomorphine

Answer 12

Anti-nausea with DOMPERIDONE (not 5HT3 antagonist) because it is emesis-producing

Question 13

Most powerful DA

Answer 13

Apomorphine

Question 14

T/F. All DAs cause confusion and hallucination

Answer 14

True

Question 15

When does leg edema with DA occur? Early or late

Answer 15

Late

Question 16

It’s important to ask about ___ when using DA esp. pramipexole and ropinirole.

Answer 16

Driving

Question 17

What are the MOAs of Amantadine?

Answer 17

• activates DA RELEASE
• inhibits DA UPTAKE
• anti-muscarinic
• anti-glutamatergic

Question 18

After how many does Amantadine kick in?

Answer 18

2 days

Question 19

Side effects of Amantadine

Answer 19

Visual hallucinations, confusion

Livedo reticularis, edema

Question 20

An acute attack of hypertension that can occur in a person taking a monoamine oxidase inhibitor (MAOI) drug who eats cheese, caused by an interaction of the MAOI with tyramine, formed in ripe cheese when bacteria provide an enzyme that reacts with the amino acid tyrosine in the cheese. Other foods and drinks that produce the same effect include pickled herring, yeast extract, and certain red wines. Also called the cheese reaction.

Answer 20

Cheese effect

Question 21

Cheese effect only happens with Type __ of MAOI

Answer 21

Type A. Type B don’t have cheese effect

Question 22

T/F. Selegiline only has mild symptomatic effects if used alone.

Answer 22

True

Question 23

T/F. Rasagiline is used in early and advanced PD

Answer 23

True

Question 24

A reversible MAOB Inhibitor

Answer 24

LAZAbemide

*return policy of LAZAda

Question 25

The only MAOB Inh. That is metabolized to methamphetamine

Answer 25

Selegiline

Question 26

Inh. Of both Type A and B MAO

Answer 26

Tranylcypromine and Phenelzine