Chap 6-Med Tx Of PD Flashcards
DA with 5-HT activity
Lisuride
*liSHUride
Longest acting DA
CaberGOLiNe
Most important DA for preventing or reducing “wearing off” bec. Of its t1/2
Cabergoline
DA with anti-tremor effect
Piribedil
*Remember enchong’s tremulous peri peri chicken dance
Weakest DA clinically
Bromocriptine
*Bromo promo
DAs with D1 activity
Lisuride, Apomorphine, Pergolide
*1 LAP
Dopamine receptor impt. For anti-PD effect
D2
T/F. It is unknown how D3 is important for anti-PD effects
True
Dopamine receptor implicated in ICD
D3
Side effects of DA
Sleep attacks, drowsiness, confusion OH Nausea Edema ICD
DA for rescue in OFF states
Apomorphine
Important pre-treatment before using apomorphine
Anti-nausea with DOMPERIDONE (not 5HT3 antagonist) because it is emesis-producing
Most powerful DA
Apomorphine
T/F. All DAs cause confusion and hallucination
True
When does leg edema with DA occur? Early or late
Late
It’s important to ask about ___ when using DA esp. pramipexole and ropinirole.
Driving
What are the MOAs of Amantadine?
- activates DA RELEASE
- inhibits DA UPTAKE
- anti-muscarinic
- anti-glutamatergic
After how many does Amantadine kick in?
2 days
Side effects of Amantadine
Visual hallucinations, confusion
Livedo reticularis, edema
An acute attack of hypertension that can occur in a person taking a monoamine oxidase inhibitor (MAOI) drug who eats cheese, caused by an interaction of the MAOI with tyramine, formed in ripe cheese when bacteria provide an enzyme that reacts with the amino acid tyrosine in the cheese. Other foods and drinks that produce the same effect include pickled herring, yeast extract, and certain red wines. Also called the cheese reaction.
Cheese effect
Cheese effect only happens with Type __ of MAOI
Type A. Type B don’t have cheese effect
T/F. Selegiline only has mild symptomatic effects if used alone.
True
T/F. Rasagiline is used in early and advanced PD
True
A reversible MAOB Inhibitor
LAZAbemide
*return policy of LAZAda
The only MAOB Inh. That is metabolized to methamphetamine
Selegiline
Inh. Of both Type A and B MAO
Tranylcypromine and Phenelzine
