Chap. 24 Pain

Question 1

Allodynia

Answer 1

Pain without cause, needs stimulus though

Question 2

Hyperalgesia

Answer 2

Pain without cause, no need for stimulus

Question 3

Bradykinin

Answer 3

Acts directly on the AB and C fibers to produce pain

also acts to modulate TRP channels

Question 4

“Winding up”

Answer 4

sensitization of nerves in the dorsal horn due to long time stimulation. NMDA action. lowers pain threshold

Question 5

Spinothalamic tract

Answer 5

Lamina I, V-VII

cross over, thalamus (CLN/VPLN)

Question 6

Spinoreticular

Answer 6

lamina VII-VIII

crossover, RF and Thalamus

Question 7

Spinomesencephalic

Answer 7

lamina I and V

crossover, RF and amygdala

Question 8

cervicothalamic

Answer 8

upper cervical segments of SC
II and IV
acend in medial lameniscus to thalamus (VPL/PMN)

Question 9

spinothalamic

Answer 9

I, V, VIII
project to hypothalamus from dorsal horn
endocrine role in pain

Question 10

Lateral Nuclear Group

Answer 10

spinothalamic input (I-V) 
encode spacial info of pain
small receptive field to do this

Question 11

Medial Nuclear group

Answer 11

Project to BG and cortex