CH4 Flashcards
Pulmonary edema is most frequently seen associated with what?
Left ventricular failure (causes a backup behind it, which is the lung vasculature)
What are heart failure cells and when are they seen?
Macrophages with lots of hemosiderin, chronic pulmonary congestion
What’s Nutmeg liver and when does it occur?
Red-brown centrilobular cells of the liver that are unhealthy (not tan) d/t chronic hepatic congestion
What process is necessary for life?
Hemostasis, the process of blood clots forming at sites of vascular injury
What is DIC?
Disseminated intravascular coagulation, where consumption of coagulation factors leads paradoxically to bleeding because no factors are left over
What are the contents of platelet granules?
TxA2 and ADP
What factor is exposed in secondary hemostasis? What does it do?
Tissue factor, pro-coagulant that binds factor VII –> thrombin generation
What does TxA2 do?
Platelet aggregator (not activator)
What mediators activate platelets?
Collagen & vWF (via GpIb), thrombin (via PAR)
What is Glanzmann thrombasthenia?
Deficiency of GpIIb/IIIa
What factor is in the extrinsic pathway that ISN’T in the intrinsic?
Factor VII
In lab, how do you activate the intrinsic and extrinsic pathways?
Intrinsic: phospholipids, calcium, negative charged substance (glass beads)
Extrinsic: tissue factor
What factors does thrombin activate? What co-factors?
XI
V and VIII
