Ch20 Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders Flashcards
What is the most common type of leukemia in older adults
CLL
Disorders that are proliferations of morphologically and immunophenotypically mature B or T lymphocytes are known as:
Chronic lymphoproliferative disorders
What is CLL characterized by?
Peripheral blood a BM lymphocytes
Small lymphocytic lymphoma involves mainly:
Lymph nodes- and a lesser extent of BM and peripheral blood
CLL cells show what type of morphology?
Increased prolymphocytes
Proliferating lymphocytes which are larger in size
Increased lymphoplasmacytoid cells
What are the consequences of accumulating lymphocyte mass in CLL?
Neutropenia
Anemia
Thrombocytopenia
Lymphadenopathy and or splenomegaly
What is the prolonged survival rate of patients with CLL?
5-10 years
Patients with CLL have a significantly impaired immunologic activity that leads to:
Bacterial infections in respiratory tract, urinary tract, and skin
Autoimmune hemolytic anemia
What percentage of normal T-cells circulate in lymphocyte peripheral blood smear?
61-89%
When does the malignancy of B lymphocytes of CLL progress normally?
Final stages of B-cell development
What is a common feature in CLL? (Common to many malignancies)
Monoclonality rather than polyclonality
What percentage of lymphocytes are in the BM in CLL?
30%
What type of anemia is seen in CLL?
Normochromic and normocytric
What is the most common chromosomal abnormality in B-CLL?
Trisomy 12
What treatment is commended for CLL patients with worsening conditions?
Chemotherapy
Sometimes radiation if lymphoid mass is localized
How can CLL be differentiated from ALL?
Chromatin in CLL is heavy and clumped
Reactive lymphocytes is most commonly caused by:
A viral infection, such as mononucleosis, viral hepatitis,
The cells of CLL are morphologically identical to those of:
Small lymphocytic lymphoma
Surface immunoglobulin is the most reliable surface marker for:
B lymphocytes
Cells that demonstrate a positive exactions with the tartrate -resistant acid phosohatase (TRAP) stain are more likely:
Hairy cells of hairy-cell leukemia
A mutated tumor suppressor gene found in a variety of human cancers, including CLL is:
p53
In chronic lymphocytic leukemia:
The absolute lymphocyte count is usually equal to or exceeds 5000 x 10^9 cells/L
The poorest prognosis for patients with CLL is associated with what features?
Anemia
Thrombocytopenia
