Ch. 86- Drugs for Weight Loss Flashcards
What percentage of people in the United States are obese?
41.9%
What contributes to an increase in comorbidities?
Excessive fat
What is the percentage of American children and adolescents that are obese?
Almost 20%
How is Body Mass Index (BMI) calculated?
Divide the patient’s weight (kg) by the square of the patient’s height (in meters)
What does a BMI of 25-29.9 indicate?
Overweight
What does a BMI greater than 30 indicate?
Obesity
What happens to the risk for comorbidities with a BMI greater than 25?
It rises
What is the best way to manage obesity?
Prevention
What is the definition of Obesity Stage 0?
BMI > 30 with no complications
What defines Obesity Stage 1?
BMI > 25 with at least one mild to moderate obesity-related complication
What defines Obesity Stage 2?
BMI > 25 and at least one severe obesity-related complication
What are the treatment modalities for obesity?
- Caloric restriction
- Exercise
- Behavioral modification
- Drug therapy
- Bariatric surgery
How much aerobic activity is recommended to lose weight per week?
At least 150 minutes
How many minutes of exercise per week are recommended to maintain weight loss?
200-300 minutes
What are Sympathomimetic Amines used for?
Decrease appetite
Name a weight loss drug that is a Sympathomimetic Amine.
Phentermine (Adipex-P, Lomaira)
What is a combination product used for weight loss?
Phentermine/topiramate (Qsymia)
What does Naltrexone/bupropion (Contrave) hypothesized to act on?
Regulation of appetite in the hypothalamus and on the mesolimbic dopamine system
What is the mechanism of action for Orlistat?
Acts in the GI tract to reduce absorption of fat
Name a GLP-1 agonist used for weight loss.
Liraglutide (Saxenda)
What is the effect of Semaglutide (Wegovy) on gastric emptying?
Slows gastric emptying
What is Tirzepatide (Zepbound) classified as?
GIP/GLP-1 Agonist
When did Tirzepatide (Zepbound) enter the market?
December 2023
