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General Patho > Ch 6To 9 > Flashcards

Ch 6To 9 Flashcards

1
Q

Macrophage name in liver , kidney,bone,placenta, brain

A 
Kuffer cells
Mesangial cells
Osteoclast
Haufbeur cells
Microglia
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2
Q

Classical activation of macrophage

A

M1 - TLR ,INF gamma - ROS , IL 1, IL12, IL23

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3
Q

Alternatively activted macrophage m2

A

IL 4 , IL 13 - TGF BETA , IL 10

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4
Q

Granuloma components

A

Modified macrophage - epithelioid cells
Surrounded by lymphocytes
Gaint cells
Necrosis

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5
Q

Granulomatous diseases

A 
TB
Sarcoidosis
Cat scratch 
Syphilis
Leprosy
Wegner
Corhn
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6
Q

Caseating granuloma

A

TB
Fungal - histoplasmosis, coccidiomycosis
Syphilis

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7
Q

Naked granuloma - lymphatic collar absent

A

Sarcoidosis

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8
Q

Palisading granuloma

A

Wegener

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9
Q

Donut granulom

A

Q fever

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10
Q

Positive acute phase reactants

A 
CRP
Fibrinogen
Serum amyloid associte
Minose binding lactin
Factor 8
VWF
Prothrombin
Ceruloplasmin
Haptoglobin
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11
Q

Per formed mediators

A

Histamine and serotonin

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12
Q

Histamine source nd function

A

Mast cell , basophil, platelets

Vasodilation, increased vascular

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13
Q

Serotonin source nd function

A

Platelets

Neurotransmitter in cns and git

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14
Q

Platelet activation factor function

A

Vasoconstriction, bronchoconstriction, increased vascular, platelet aggregation

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15
Q

Nitric oxide function

A

Smooth muscle relaxation
Vasodilation
Decreases platelets aggregation
Microbicidal action

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16
Q

Arachidonic acid metabolites

A

Cycloxygenase - prostacyclin , prostaglandin, thromboxane

Lipoxgenase - lipoxin and leukotrines

17
Q

Prostacyclins present and function

A

In vascular endothelium

Vasodilation, decreses platelet aggregation

18
Q

Thromboxane

A

In platelet

Function- vasoconstriction, increased platelet aggre

General Patho (2 decks)

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