Ch 5 - Pharmacotherapy in Pregnancy & Lactation

Question 1

Reduced absorption:

Decreased GI motility delays absorption. Decreased gastric acid and increased gastric mucus secretion cause increased gastric pH (alkaline). Nausea and vomiting cause increased progesterone levels.

Answer 1

Factors affecting GI absorption in pregnancy

Question 2

Enhanced absorption:

Increased cardiac and tidal volume cause hyperventilation and increased pulmonary blood flow.

Answer 2

Factors affecting Lung absorption in pregnancy

Question 3

Enhanced absorption:

Increased peripheral vasodilation, increased blood flow to skin, increased total body water.

Answer 3

Factors affecting Transdermal absorption in pregnancy

Question 4

Volume of total body water during pregnancy. Increased body water causes drug concentrations to be diluted.

Answer 4

8 Liters

Question 5

Percentage of blood volume increase during pregnancy.

Answer 5

30-50%

Question 6

Increase in maternal ______ _______ during pregnancy act as a reservoir for lipid soluble drugs.

Answer 6

Fat deposits

Question 7

Decreased plasma levels of this protein cause reduced drug-protein binding and allow for increased free drug.

Answer 7

Albumin

Question 8

Increase in this hormone can stimulate hepatic microsomal enzyme systems, increasing elimination of some hepatically eliminated drugs and decrease elimination of others.

Answer 8

Progesterone

Question 9

Increased renal blood flow by 50% and increased ____ ____ ____ cause increased drug elimination from the kidneys

Answer 9

Glomerular filtration rate