Ch 39 Flashcards
Electrolytes
- Substances that develop an electrical charge when dissolved in water
- Responsible for maintaining the fluid balance between intracellular and extracellular. Important because it helps with hydration, nerve impulses, muscle function, pH level
- Important because cells, tissues, and fluids thrive in a homeostatic environment
Cation
Electrolytes that carry a positive charge
Anion
Electrolytes that carry a negative charge
Interstitial fluid
lies between the spaces in the blood
Intravascular fluid
lies in the plasma within the blood
Transcellular fluid
includes specialized fluids like cerebrospinal, pleural, peritoneal, and synovial fluid
Active transport
- movement of fluid and solutes that requires energy
- Molecules (solute)
- low concentration to high concentration
Passive transport
- movement of fluid and solutes that does not require energy.
- 3 types: osmosis, diffusion, filtration
Osmosis
Water
low concentration to high concentration
Diffusion
Molecules (solute)
high concentration to low concentration
Filtration
Water and small particles
high pressure to low pressure
Sensible fluid loss
measurable and perceived
urine, diarrhea, ostomy, gastric drainage
Insensible fluid loss
not perceived and not easily measured
evaporated from the skin and lungs
Sodium (Na+)
- Major cation in the ECF
- Normal serum level is 135-145 mEq/L
Function:
- Regulates fluid vol.
- Maintains blood vol.
- Interacts with calcium to maintain muscle contraction
- Stimulates conduction of nerve impulses
Regulation:
- Moves by Active transport
- Regulates aldosterone and ADH levels
- Reabsorbed and excreted through kidneys
- Minimal loss through perspiration and feces
- Low sodium may be caused by excess water intake
Sources:
Table salt, soy sauce, cured pork, cheese, milk, processed foods, canned products, foods preserved with salt
Potassium (K+)
- Major cation in ICF
- Normal serum level 3.5-5 mEq/L
Function:
- Maintains ICF osmolality
- Regulates conduction of cardiac rhythm
- Transmits electrical impulses in multiple body systems
- Assists with acid-base balance
Regulation:
- Regulated by aldosterone
- Excreted and conserved through the kidneys
- Lost through vomiting and diarrhea
- Lost triggered by many diuretics
Sources:
bananas, oranges, apricots, figs, dates, carrots, potatoes, tomatoes, spinach, dairy products, and meats
Calcium (Ca2+)
- Most abundant electrolyte in the body
- Normal serum level 8.5-10.5 mg/dL
Function:
- Promotes transmission of nerve impulses
- Major component of bone and teeth
- Regulates muscle contraction
- Maintains cardiac automaticity
- Essential factor in the formation of blood clots
- Catalyst for many cellular activities
Regulation:
- Combines with phosphorus to form the mineral salts of the teeth and bone
- Calcium and phosphorus levels inversely proportional
- Parathyroid hormone (PTH) stimulates release from bone and reabsorption for kidneys and intestines
- Calcitonin (from the thyroid) blocks bone breakdown and lowers calcium levels
- Absorption stimulated by vitamin D
Sources:
-Milk, milk products, dark green veggies, salmon, breads and cereals
Magnesium (Mg2+)
- Presents in skeleton and ICF
- Second most abundant cation in ICF
- Normal serum level is 1.6-2.6 mEq/L
Function:
- Involved in protein and carbohydrate metabolism
- Necessary for protein and DNA synthesis within the cell
- Maintains normal intracellular levels of potassium
- Involved in electrical activity in nerve and muscle membranes, including the heart
- May have a role in regulating BP and may influence the release and activity of insulin
Regulation:
- Ingested in the diet and absorbed through the small intestine
- Excreted by kidneys
- Loss may be triggered by diuretics, poorly controlled DM, and excess alcohol intake
Sources:
- Average daily requirement is 18-30 mEq
- most foods, high levels present in green veggies, cereal, grains, and nuts
Chloride (CI-)
- Major anion in the ECF
- Normal serum level is 95-105 mEq
Function:
- Works with Na+ to maintain osmotic pressure between fluid compartments
- Essential for production of HCI for gastric secretions
- Functions as buffer in oxygen-carbon dioxide exchange in RBCs
- Assists with acid-base balance
Regulation:
- Reabsorbed and excreted through the kidneys along with sodium
- Regulated by aldosterone and ADH levels
- Deficits lead to potassium deficits; potassium deficits lead to chloride deficits
Sources:
-foods high in sodium
Phosphate (PO4-)
- Major anion in the ICF
- Normal serum level is 1.7-2.6 mEq/L
Function:
- Serves as a catalyst for many intracellular activities
- Promotes muscle and nerve action
- Assists with acid base balance
- Important for cell division and transmission of hereditary traits
Regulation:
- Combines with calcium to form the mineral salts of the teeth and bones
- Calcium and phosphorus levels inversely proportional
- Regulated by PTH; has inverse response to calcium
- Excreted and reabsorbed by the kidneys
Sources:
- meat, fish, poultry, milk products, carbonated beverages, legumes
- Readily available in body as a result of metabolism
Bicarbonate (HCO3-)
- Major buffer in the body
- In ECF and ICF
- Normal serum level is 22-26 mEq/L
Function:
-Maintains acid-base balance by functioning as the primary buffer in the body
Regulation:
- Lost through diarrhea, diuretics, renal insufficiency
- Excess possible if person ingests quantities of acid neutralizers
Hydrostatic pressure
- The force created by fluid within a closed system
- It is responsible for normal circulation of blood
Osmotic pressure
the power of a solution to draw water
The IOM recommends a total fluid intake of
women- 2700ml/day
men- 3700 ml/day
What is the principal regulator of fluid and electrolyte balance
the kidneys
Renin
enzyme responsible for the chain of reactions that converts angiotensinogen to angiotensin II
Angiotensin II
Acts on the nephrons to retain sodium and water and directs the adrenal cortex to release aldosterone
Thyroid hormone affects fluid volume by?
influencing cardiac output