CH 3: Toxic Effects of Drugs

Question 1

blood dyscrasia

Answer 1

bone marrow depression caused by drug fx on the rapidly multiplying cells of the bone marrow

Question 2

dermatological rxns

Answer 2

adverse rxns involving the skin

Question 3

drug allergy

Answer 3

• formation of antibodies to a drug or drug protein

- causes an immune response when the person is re-exposed to that drug

Question 4

hypersensitivity

Answer 4

excessive responsiveness to either the primary or secondary fx of a drug

Question 5

poisoning

Answer 5

overdose of a drug that causes damage to multiple body systems & has the potential for fatal rxns

Question 6

stomatitis

Answer 6

inflammation of the mucous membranes related to drug fx

Question 7

superinfections

Answer 7

infections caused organisms usually cnotrolled by the normal flora, which allow other bacteria to enter the body & cause infection

Question 8

anaphylactic rxn

Answer 8

an antibody reacts w/ specific sites in the body to cause the release of chemicals (including histamine) that produce immediate rxns that can lead to respiratory distress

Question 9

cytotoxic rxn

Answer 9

antibodies circulate in the blood & attack antigens (the drug) on cell sites, causing death of that cell

Question 10

serum sickness rxn

Answer 10

antibodies circulate in the blood & cause damage to various tissues by depositing in blood vessels

Question 11

delayed allergic rxn

Answer 11

occurs several hrs after exposure & involves antibodies that are bound to specific wbc’s

Question 12

normal flora

Answer 12

bacteria living w/in or on the surface of the body that protects the body from invasion by other bacteria