Ch. 3 Drug Interactions

Question 1

define pharmacodynamics vs. pharmacokinetics

Answer 1

PD - effect drug has on the body
ex. alcohol causes drunkenness

PK - effect body has on the drug
ex. ADME processes

Question 2

CYP enzyme inhibitors ___________ the concentration of substrate drugs.
Examples of common CYP inhibitors

Answer 2

CYP enzyme inhibitors __INCREASE__ the concentration of substrate drugs.

example: G-PACMAN
- Grapefruit
- Protease inhibitors (PIs) (ritonavir)
- Azole antifungals (fluconazole)
- Cyclosporine, cobicistat
- Macrolides (clarithromycin, erythromycin, NOT azithromycin)
- Amiodarone
- Non-DHP CCBs (diltiazem, verapamil)