Ch. 3 (Clayton)- drug action across the lifespan

Question 0

polymorphisms

Answer 0

naturally occurring variations in the structures of genes and the instructions that they give the organism

Question 1

genome

Answer 1

complete package of genetic coding of an organism

*23 chromosome pairs; 22 are autosomal (non-gender related)

Question 2

stevens-johnson syndrome & toxic epidermal necrolysis

Answer 2

fatal skin reaction
can be caused by carbamazepine therapy in pt’s w/ leukocyte antigen
most common in persons of asian & s. asian indian ancestry

Question 3

passive diffusion

Answer 3

absorption across the membranes and gastric emptying

Question 4

woman’s stomach vs. man’s

Answer 4

woman’s stomach empties solids more slowly and has greater gastric acidity

increase chance of toxicity due to duration in stomach

lower levels of an gastric enzyme

Question 5

drug distribution is dependent on…?

Answer 5

ph
body water concentrations
quantity of fat tissue
protein binding
cardiac output
regional blood flow

Question 6

water composition of adult man

Answer 6

60%