ch 28 collection and analysis of bone marrow

Question 1

What is an indication for bone marrow aspirate?

Answer 1

–unexplained nonregenerative anemia, neutropenia, thrombocytopenia, pancytopenia
–observation of atypical cells, unexplained immature cells or abnormal blood cell morphology on peripheral blood smear

Question 2

What is the life span of platelets?

Answer 2

–7 to 10 days

Question 3

What is the average life span of large animal RBCs?

Answer 3

–approximately 5 months

Question 4

What is the disadvantage of bone marrow aspirate vs biopsy?

Answer 4

the architecture cannot be assessed with an aspirate
**it can be impossible to confirm whether a poor cellular sample is a result of a pathologic process or unsatisfactory sampling

Question 5

Which type of bone marrow sample provides a better assesment of bone marrow cellularity & is a better confirmation of myelofibrosis?

Answer 5

bone marrow–core biopsy

Question 6

what are sites for bone marrow aspirate in large animals?

Answer 6

sternum
ribs
iliac crest

Question 7

Lack of iron stores on bone marrow biopsy are suggestive of?

Answer 7

iron deficiency

Question 8

abundant iron stores on bone marrow biopsy are associated with

Answer 8

anemia of chronic inflammation

Question 9

What is the best way to assess erythropoiesis in horses?

Answer 9

to examine bone marrow

Question 10

atypical cell populations observed on bone marrow aspirate is indicative of what disorders?

Answer 10

-myeloproliferative disorder
-infiltrative neoplastic process
-inflammation
-antigenic stimulation

Question 11

What are signs of bone marrow necrosis on bm biopsy?

Answer 11

degenerative cells
amorphous proteinaceous debris

Question 12

bone marrow necrosis can occur by what processes?

Answer 12

-secondary to infarction, neoplasia or inflammation