Ch. 25: Skin

Question 1

PTEN

Answer 1

Cowden Syndrome (Trichellomomomas, Breast/endometrial/other CAs)

Question 2

NBCC + Ovarian fibroma + Medulloblastoma

Answer 2

Gorlin Syndrome

Question 3

Age Spots, do not darken with sun

Answer 3

Lentigo

Question 4

BRAF, TERT, loss CDKN2A

Answer 4

Dysplastic Nevi & Melanoma

Question 5

FGFR3; Lesser Trelat sign, Coin-lesion

Answer 5

Seborrheic Keratoses (GI CA)

Question 6

p53, Cutaneous Horns, Elastosis, Intercellular bridges intact, incr. risk of SCC

Answer 6

Actinic Keratosis

Question 7

Most common CA, gain Hedgehog, loss PTCH, pearly papules, telengiactasia, UPPER lip, palisading, assoc w/ single bad intense sunburn

Answer 7

BCC

Question 8

2nd most common CA, assoc w/ lifetime sun exposure and HPV5/8, p53, RAS, Notch, Red scaly plaques, wart like, LOWER lip

Answer 8

SCC

Question 9

Factor XIIIa + dermal dendritic cells; mostly in legs of young girls; inward dimpling; spindle shaped fibroblasts; pseudoepitheliomatous hyperplasia

Answer 9

Dermatofibroma

Question 10

COL1A1, PDGFB; firm nodules; storeroom fibroblasts in pinwheel form; honeycomb extension into SQ; thin overlying epi

Answer 10

Dermatofibrosarcoma Protuberans

Question 11

Pautrier Microabscess

Answer 11

Mycosis Fungiodies

Question 12

KIT mutation, single nodule, spindle and stellate cells; pruritus and flushing; Darier sign; Dermatographism

Answer 12

Mastocytosis

Question 13

Fish-like scale

Answer 13

Ichthyosis

Question 14

Oozing, crusted, papulovesicular, spongiosis, intraepidermal vesicles

Answer 14

Acute Eczema/Dermatitis

Question 15

Target lesion, Type IV Hyp, Atypical PNA or drugs or CT Dz, Assoc: SJS and Toxic Epidermal Necrosis

Answer 15

Erythema Multiforme

Question 16

HLA-Cw0602; Koebner Phenomenon; Auspitz sign, Munro Microabscess

Answer 16

Psoriasis

Question 17

Yellow dandruff, greasy, follicular lipping

Answer 17

Seborrheic Dermatitis

Question 18

Wickham Striae; Koebner Phenomenon; Symmetric; Net-like reticular lesions; Jagged sawtooth rete ridges; Civatte bodies

Answer 18

Lichen Planus

Question 19

IgG to Desmogleins (Desmosomes); Net-like reticular; Thin-roofed bulla; crusty, SUPRABASILAR

Answer 19

Pemphigus

Question 20

IgG to BPAG in BM; Linear deposits; SUBEPIDERMAL; Tense bullae (difficult to rupture)

Answer 20

Bullous Pemphigoid

Question 21

IgA to gluten/gliadin (assoc: Celiac Dz); rxn to reticulin; Extensor surfaces affected; SUBEPIDERMAL @ tips of dermal papillae; Grouped Vesicles

Answer 21

Dermatitis Herpetiformis

Question 22

Keratin 5/14; Laminin mutation or BPAG2; COL7A1; non-inflammatory

Answer 22

Epidermolysis Bullosa

Question 23

Rhinophyma; High Cathelicidin; Granulomatous responses; Blotchy erythema and telengiactasias

Answer 23

Rosacea

Question 24

SQ adipose inflamm; Bruise-like; lower legs; assoc: IBD

Answer 24

Erythema Nodosum

Question 25

Umbillicated pink papules; pruritic; curd-like material with inclusion bodies on stain

Answer 25

MCV

Question 26

Honey-colored crust after infection w/ S/ Aureus; affect Desmoglein 1

Answer 26

Impetigo