ch 24 Flashcards

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1
Q

Which statement about hemoglobin is false?

a. It plays a role in CO2 transport.
b. It plays a role as a pH buffer.
c. It plays a role in N2 transport.
d. It is affected by temperature.

A

c

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2
Q

Which statement comparing human adult and fetal hemoglobin is true?

a. Fetal hemoglobin contains one particular subunit that lowers its P50.
b. Fetal hemoglobin contains one particular subunit that raises its P50.
c. All subunits of fetal hemoglobin are different and result in a lower P50.
d. All subunits of fetal hemoglobin are different and result in a higher P

A

a

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3
Q

Which statement about myoglobin is true?

a. It is a respiratory pigment found in the red blood cell.
b. It is exactly like hemoglobin but is found in a different location in the bod
c. It is a type of fetal hemoglobin.
d. It is a respiratory pigment found in muscle cytoplasm

A

d

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4
Q

The image on a graph showing the functional relationship between the percentage of
oxygenated binding sites and the O2 partial pressure is best known as
a. the saturation curve.
b. the affinity curve.
c. the P50 curve.
d. the oxygen dissociation curve

A

d

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5
Q
A respiratory pigment that requires a relatively low O2 partial pressure for loading has
\_\_\_\_\_\_\_ affinity for O2.
a. a low
b. a high
c. no
d. a variable
A

b

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6
Q
In a healthy human at rest, what is the approximate O2 saturation of venous blood as it
is leaving the tissues?
a. 75%
b. 50%
c. 25%
d. 0%
A

a

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7
Q

A respiratory pigment that requires a relatively low O2 partial pressure for loading
and has a high affinity for O2 would also have
a. a relatively low P50.
b. a relatively high P50.
c. no P50 at all.
d. a variable P50

A

a

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8
Q
The effect of acid in reducing the affinity of hemoglobin for O2 is called the \_\_\_\_\_\_\_
effect.
a. Haldane
b. dissociation
c. Root
d. Bohr
A

d

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9
Q

Which statement is not directly related to the Bohr effect?
a. The Hb‒O2 affinity increases as pH increases.
b. The Hb‒O2 affinity decreases as temperature increases.
c. The Hb‒O2 affinity decreases as CO2 partial pressure increases.
d. The Hb‒O2 affinity decreases as H+
concentration increases.

A

b

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10
Q
The affinity of hemoglobin for O2 increases with
a. decreasing temperature.
b. decreasing blood pH.
c. an increase in CO2 partial pressure.
d. increasing [H+
].
A

a

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11
Q
The venous blood displays a reduced O2 affinity compared to arterial blood because
its
a. CO2 partial pressure is higher.
b. H+
concentration is higher.
c. hemoglobin concentration is lower.
d. CO2 partial pressure is higher and its H+
concentration is higher.
A

d

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12
Q

During chronic exposure to high altitude, increasing 2,3-DPG

a. increases Hb‒O2 affinity.
b. increases the unloading of O2 at tissues.
c. increases the loading of O2 at the lungs.
d. decreases the P50 of hemoglobin

A

b

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13
Q

Which statement about respiratory pigments is false?

a. They serve as major buffers of blood pH.
b. They play critical roles in CO2 transport.
c. They play critical roles in the transport of nutrients.
d. They can function as O2 stores in invertebrates.

A

c

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14
Q

An octopus meets the increased demand for O2 at the tissues during intense exercise
by
a. increasing its circulation rate.
b. pulling more O2 from the blood (from its venous reserve).
c. switching to another form of hemoglobin.
d. increasing its circulation rate and pulling more O2 from the blood (from its venous
reserve).

A

a

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15
Q

The P50 in a fish species adapted to a low oxygen aquatic environment would likely
be _______ the P50 of a fish species adapted to a well-oxygenated aquatic environment.
a. higher than
b. equal to
c. lower than
d. extremely variable compared to

A

c

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16
Q

The exposure of Daphnia to O2-poor water for days would result in
a. an increase in hemoglobin concentration.
b. a change in the globin subunits produced.
c. an increase in hemoglobin concentration and a decrease in the P50 of the blood.
d. an increase in hemoglobin concentration, a decrease in the P50 of the blood, and a
change in the globin subunits produced

A

d

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17
Q

Antarctic icefish compensate for the lack of circulating red blood cells with

a. an increase in the amount of hemoglobin in their plasma.
b. the use of another type of respiratory pigment.
c. an increased circulation rate.
d. a lowering of their metabolic rate, along with general inactivity.

A

c

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18
Q

In many cases, lowland people who travel to an area of high altitude for an extended
period of time will develop a condition known as
a. polycythemia.
b. anemia.
c. bradycardia.
d. hypotension.

A

a

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19
Q

The extent of bicarbonate formation in the blood depends primarily on the

a. solubility of bicarbonate in the plasma.
b. temperature.
c. blood buffers.
d. solubility of carbonic acid.

A

c

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20
Q

The buffering effectiveness of any given buffer reaction is greatest when the
prevailing pH _______ the pK´ of the reaction.
a. is much greater than
b. matches
c. is much lower than
d. is as far away as possible from

A

b

21
Q

What determines the shape of the CO2 equilibrium curve?
a. The kinetics of HCO3

formation
b. The amount of dissolved CO2
c. The number of carbamate groups and the amount of dissolved CO2
d. The kinetics of HCO3

formation, the number of carbamate groups, and the amount of
dissolved CO2

A

d

22
Q

The deoxygenation of hemoglobin promotes CO2 uptake and the oxygenation of
hemoglobin promotes the unloading of CO2. This phenomenon is called the _______
effect.
a. Root
b. fixed-acid Bohr
c. Haldane
d. CO2 Bohr

A

c

23
Q

Which species would have the highest total blood CO2 concentration?

a. Human
b. Turtle
c. Lungfish
d. Trout

A

b

24
Q

The key enzyme involved in the formation of bicarbonate from CO2 is

a. lactate dehydrogenase.
b. alcohol dehydrogenase.
c. carbonic anhydrase.
d. bicarbonate dehydrogenase.

A

c

25
Q

The chloride shift refers to

a. rapid anion exchange proteins.
b. carbonic anhydrase.
c. carbamate formation.
d. the dissolving of CO2 in plasma.

A

a

26
Q

In mammals, the bulk of the CO2 is transported from the tissue to the lungs as

a. bicarbonate dissolved in the plasma.
b. CO2 dissolved in the plasma.
c. CO2 bound to hemoglobin.
d. bicarbonate bound to hemoglobin.

A

a

27
Q

The alphastat hypothesis attempts to explain why _______ as temperature falls.

a. blood pH of ectotherms decreases
b. blood pH of ectotherms increases
c. muscle pH of ectotherms decreases
d. blood pH of endotherms decreases

A

b

28
Q
Which of the following is(are) the main organ(s) responsible for adjusting blood pH
in terrestrial animals?
a. Lungs
b. Kidneys
c. Lungs and kidneys
d. Lungs, kidneys, and liver
A

c

29
Q
If exhalation of CO2 is abnormally increased relative to production, the likely result
will be
a. respiratory acidosis.
b. metabolic acidosis.
c. metabolic alkalosis.
d. respiratory alkalosis
A

d

30
Q

Which statement regarding hemoglobin is false?

a. Its affinity for O2 can change.
b. It is primarily an enzyme.
c. It binds to O2 via weak, noncovalent bonds.
d. It is a buffer.

A

b

31
Q
How many molecules of O2 does a molecule of vertebrate blood hemoglobin normally
bind?
a. 1
b. 2
c. 4
d. 8
A

c

32
Q

Which statement about the four chemical classes of respiratory pigments is true?
a. All are metalloproteins.
b. All bind reversibly with O2 at specific O2-binding sites associated with metal ions.
c. All share the same heme structure.
d. All are metalloproteins and bind reversibly with O2 at specific O2-binding sites
associated with metal ions.

A

d

33
Q

In people at rest, the approximate O2 saturation of venous blood leaving the tissues is

a. 75%.
b. 5 ml O2/100 ml blood.
c. 10 ml O2/100 ml blood.
d. 5%.

A

a

34
Q

During exercise, the body supplies O2 to the muscles by
a. increasing muscle fiber declination.
b. increasing blood flow.
c. increasing blood flow and unloading more O2 to tissues from hemoglobin.
d. increasing muscle fiber declination, increasing blood flow, and unloading more O2 to
tissues from hemoglobin.

A

c

35
Q
The extent of O2-binding site cooperativity is expressed using a mathematical index
called the
a. Bohr effect.
b. Root index.
c. Haldane constant.
d. Hill coefficient.
A

d

36
Q
Which word best describes the mechanism for the steep portion of the oxygen
dissociation curve?
a. Cooperativity
b. Loading
c. Unloading
d. Coefficient
A

a

37
Q
The process by which low pH aids in the decreasing affinity of hemoglobin for O2 is
called the \_\_\_\_\_\_\_ effect.
a. Bohr
b. Root
c. Haldane
d. hemoglobin-shift
A

a

38
Q

Which statement about the Bohr effect is true?
a. A higher temperature decreases the Hb‒O2 affinity.
b. A lower pH increases the Hb‒O2 affinity.
c. A higher partial pressure of CO2 decreases the Hb‒O2 affinity.
d. A higher H+
concentration increases the Hb‒O2 affinity

A

c

39
Q

Which variable does not affect the properties of the O2 dissociation curve?

a. Temperature
b. Partial pressure of CO2
c. 2,3-DPG concentration
d. Cardiac output

A

d

40
Q

Which hemoglobin has the highest P50?

a. Hemoglobin at a lower-than-normal temperature, such as 35°C
b. Fetal hemoglobin
c. Hemoglobin in a human residing at a high altitude for three weeks
d. Hemoglobin at a higher-than-normal pH, such as 7.6

A

c

41
Q
A reduction in the amount of O2 bound to hemoglobin at saturation could be the result
of the \_\_\_\_\_\_\_ effect.
a. Bohr
b. fixed-acid Bohr
c. Root
d. Haldane
A

c

42
Q

During chronic exposure to high altitude, increased 2,3-DPG

a. increases hemoglobin‒O2 affinity.
b. increases the unloading of O2 at tissues.
c. permits increased physical exercise.
d. increases the loading of O2 at the lungs.

A

b

43
Q

During exercise, squids and octopuses meet their O2 demand by

a. drawing additional O2 from venous reserve.
b. increasing their circulation rate.
c. increasing the affinity of hemoglobin for O2.
d. decreasing the affinity of hemoglobin for O2.

A

b

44
Q

In general, what is the relationship between primate size and Hb‒O2 affinity?

a. Larger primates tend to have a lower Hb‒O2 affinity.
b. Smaller primates tend to have a lower P50.
c. Larger primates tend to have a higher P50.
d. Smaller primates tend to have a lower Hb‒O2 affinity.

A

d

45
Q

Compared to oxygenated blood, fully deoxygenated blood has a

a. higher affinity for CO2.
b. lower affinity for CO2.
c. higher affinity for bicarbonate.
d. lower affinity for O2.

A

a

46
Q

Bicarbonate created from CO2 in the red blood cell gets into the plasma
a. through exclusive bicarbonate channels.
b. via chloride exchange.
c. with the assistance of carbonic anhydrase, which shuttles it into the plasma.
d. via active transport in exchange for Na+
.

A

b

47
Q

Which of the following is(are) involved in the transport of CO2 from the tissues to the
lungs?
a. Bicarbonate
b. Bicarbonate and CO2 bound to hemoglobin
c. CO2 bound to hemoglobin and CO2 dissolved in plasma
d. Bicarbonate, CO2 bound to hemoglobin, and CO2 dissolved in plasma

A

d

48
Q

According to the _______, changes in pH are a means by which ectotherms maintain
a constant state of electrical charge on protein molecules.
a. Root effect
b. Bohr shift
c. alphastat hypothesis
d. law of buffered reactions

A

c