Ch. 23 Cell Death

Question 1

Pathological >Injury or disease > Groups of cells are induced to die > Passive; damages neighboring cells > Inflammation

Answer 1

Necrosis

Days

Question 2

Physiological > Programmed cell death > Active; no damage to neighboring cells >
No inflammation

White Blood Cells**

Answer 2

Apoptosis

hours

Question 3

Due to injury or disease

Cells increase in size & lyse

inflammatory

Answer 3

Necrosis

Question 4

moves from inner to outer leaflet

Apoptosis

Answer 4

Phosphatidylserine

Apoptosis

Question 5

Mitochondria release

Apoptosis

Answer 5

cytochrome c

Apoptosis

Question 6

……………………… in nucleus condenses/ shuts down

Apoptosis

Answer 6

Chromatin

Apoptosis

Question 7

Specialized white blood cell preventing inflammation

Apoptosis

Answer 7

Macrophage

Apoptosis

Question 8

Cytochrome c exits mitochondria

Answer 8

Apoptosis Initiation – Internal Signal

Question 9

Cytochrome c triggers

Answer 9

apoptosome

Question 10

Death receptors can initiate apoptosis (tumor necrosis factor receptor) > Ligands contain a …………………… > cytochrome c

Answer 10

‘death domain’

External Signal

Question 11

Major function is apoptosis

Answer 11

Caspases

Question 12

prodeath signals > prosurvival

Answer 12

apoptotic cells

Question 13

Members of Bcl-2 family (the BAD proteins)

Answer 13

Prosurvival (antiapoptotic)

Question 14

• Bak & Bax proteins

* Signal permeation of the mitochondria

Answer 14

Prodeath (apoptotic)

Question 15

type 1 diabetes

Answer 15

Autoimmune diseases

Question 16

• Altered neuronal apoptosis in patients with schizophrenia

* Localized apoptosis in many forms of dementia, including Alzheimer’s disease

Answer 16

Neurodegenerative diseases