Ch. 22 Abnormal Cell Growth Flashcards
1
Q
- Proteins from these genes control cell growth & differentiation
- Examples: epidermal growth factor, Ras, Raf, Src, cyclins
A
Protooncogenes
2
Q
- Proteins from these genes control cell growth & differentiation
- Examples: epidermal growth factor, Ras, Raf, Src, cyclins
A
Protooncogenes
3
Q
Protooncogenes ,If mutated are called
A
oncogenes
4
Q
Controls unregulated progression through cell cycle
A
Tumor Suppressor Genes
5
Q
Most common mutation =
A
TP53 (codes for p53 protein)
6
Q
- Controls genes for growth regulation
- Facilitates DNA repair
- Signals apoptosis, if necessary
A
p53 protein
7
Q
Therapy would require death or removal of all tumor cells as a cure
A
Clonal Evolution Model
8
Q
•
A
Stem Cell Theory
9
Q
Cancer development is a stepwise process
A
Stage 1-4
progression, Metastasis
10
Q
(Cancer development)
Initial genetic insult
A
Initiation
11
Q
(Cancer development)
Multiple mutations lead to an increased number of mutated cells
A
Promotion
12
Q
(Cancer development)
Tumor development
A
Progression
13
Q
(Cancer development)
Tumor cell invasion
A
Metastasis
14
Q
Self-sufficient growth signals Ignores anti-growth signals Evades apoptosis Limitless replication potential Angiogenesis (new blood supply using VEGF) Reprogramming energy metabolism Evading immune destruction Metastasis
A
Hallmarks of Cancer
15
Q
The more …….. the mutation, the higher the……….. of cancer is to the individual
A
rare, risk
