Ch 22 Carbonyl alpha-substitution reactions Flashcards by Megan Mitchell | Brainscape

Q

Aldehyde / Ketone halogenation

A

CH3CO2H

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Q

Hell-Volhard-Zelinskii bromination of acids

A

1) Br2, PBr3 / 2) H2O

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Q

Dehydrobromination of alpha-bromo ketones

A

pyridine, heat

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Q

Haloform reaction

A

X2, NaOH

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Q

Alkylation of enolate ions: Malonic Ester Synthesis

A

1) Na+ -OEt, ethanol / 2) RX and H2SO4, heat

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Q

Alkylation of enolate ions: Direct alkylation of ketones

A

1) LDA in THF / 2) R’X

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Q

Alkylation of enolate ions: Direct alkylation of esters

A

1) LDA in THF / 2) R’X

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