Ch 2: Basic Science Concepts Flashcards
SLUDD
Increase:
Salivation
Lacrimation (tears)
Urination
Diarrhea/defecation
Digestion
Parasympathetic: “Rest & Digest”
What receptors does Acetylcholine act on?
Muscarinic
Nicotinic
What happens when muscarinic receptors are activated?
↑ SLUDD
What happens when nicotinic receptors are activated?
↑ HR & BP
What receptors does ephinephrine act on?
Alpha-1
Alpha-2
Beta-1
Beta-2
What receptors does norepinephrine act on?
Alpha-1
Alpha-2
Beta-1
What happens when alpha-1 receptors are activated?
Smooth muscle vasoconstriction
↑ BP
Mainly peripheral
What happens when alpha-2 receptors are activated?
↓ release of Epi & NE
↓ BP & HR
Mainly Brain, Central
What happens when beta-1 receptors are activated?
Increase:
myocardial contractility
CO
HR
Mainly Heart
What happens when beta-2 receptors are activated?
Bronchodilation
Mainly Lungs
How to identify Amide-type anesthetics?
“i” in their name before the “-caine” ending
e.g. lidocaine, bupivacaine, ropivacaine
Hypertensive Crisis
S/Sx
HTN
Tachycardia
Agitation
Death
Hypertensive Crisis
Drugs/Foods that ↑ catecholamines
bupropion
SNRIs
TCAs
stimulants
levodopa
linezolid
methylene blue
tyramine (from food)
Serotonin Syndrome
S/Sx
Tremor
Akathisia (can’t remain still)
Clonus (involuntary & rhythmic muscle contrations)
Hyperthermia
Sweating
Serotonin Syndrome
Drugs/Foods that ↑ 5-HT
SSRIs
SNRIs
TCAs
mirtazapine
trazodone
triptans
opioids
tramadol
buspirone
lithium
dextromethorphan
St. John’s wort
