Ch 18: Overview of Metabolism Flashcards
Metabolism
Metabolism is….
Sum total
Metabolism
Catabolism
Breaks Down Complex Molecules (Exergonic)
Metabolism
Exergonic
Produce Energy
Metabolism
Anabolism
Synthesize molecules/combines simple molecules into complex ones (Endergonic)
Metabolism
Endergonic
Consumes Energy
Metabolic Pathways
Metabolic Pathways
Pathway arrangement of chemical reactions in cells where the product of one reaction is the substrate for the next reaction
Metabolic Pathways
Every chemical reaction in metabolism is…
catalyzed by an enzyme
Metabolic Pathways
Enzymes are used…
like valves to control the flow of material through metabolic pathways
Metabolic Pathways
Non-spontaneous Reactions
Thermodynamically unfavorable
Metabolic Pathways
Spontaneous Reactions
Thermodynamically Favorable
Metabolic Pathways
Non-spontaneous reactions are driven by….
coupling them to spontaneous reactions.
Metabolic Pathways
TCA Cycle
(tricarboxylic acid cycle/Krebs cycle/citric acid cycle)
All metabolic pathways eventually converge into the TCA cycle
ATP
ATP is the….
Universal Currency of Free Energy
ATP
ATP is also…
one of the common links between catabolism and anabolism
shuttles chemical energy between them
Mechanisms of ATP Generation
Substate Level Phosphorylation
Transferring high-energy phosphate group from an intermediate directly to ADP
Mechanisms of ATP Generation
Oxidative Phosphorylation
Removes electrons and passes them through the electron transport chain to oxygen
generates an electrochemical gradient which drives fromation of ATP
Mechanisms of ATP Generation
Photophosphorylation
Chlorophyll Photosynthesis
only in chlorophyll containing plants
Protein/AA Catabolism
Deamination
amino group removal from amino acids so they can enter the TCA Cycle
Protein/AA Catabolism
Amino acids are ……… to produce ……….
oxidized, ATP
Protein/AA Anabolism
Protein synthesis from amino acids is called ……… and carried out in …………
Translation, Ribosomes
Protein/AA Anabolism
The Essential Amino Acids are:
Val, Leu, Ile, Met, Trp, Phe, Thr, Lys, His
Protein/AA Anabolism
Essential AA must be ….
Present in the diet as they cannot be synthesized
Protein/AA Anabolism
How can the rest of the AA be synthesized?
In body cells using Transamination
Protein/AA Anabolism
What 2 parts are needed for Transamination?
Carbon Skeleton and amino group
Amino group adds onto carbon skeleton to farm AA
Nucleic Acid and Nucleotide Catabolism
DNA and RNA are degraded by …..
enzymes
Nucleic Acid and Nucleotide Catabolism
Nucleotides are degraded into ……. by ………
Nucleosides, enzymes
Nucleic Acid and Nucleotide Catabolism
Nucleosides are degraded into ……. by …….
bases, enzymes
Nucleic Acid and Nucleotide Catabolism
What bases are nucleosides degraded into?
Purines and pyrimidines
Nucleic Acid and Nucleotide Catabolism
What does Purine degrade into?
uric acid
Nucleic Acid and Nucleotide Catabolism
What does pyrimidine degrade into?
CO2, NH3, and B-AA
B= beta
Nucleic Acid and Nucleotide Anabolism
DNA goes through what types of anabolism?
Replication, Repair, and Recombination
Nucleic Acid and Nucleotide Anabolism
RNA goes through what types of anabolism?
synthesis and processing
Nucleic Acid and Nucleotide Anabolism
What types of nucleotide synthesis is there?
De Novo and the Salvage Pathway
Carbohydrate Catabolism
Starch and glucose are broken down by enzymes to produce…..
glucoses
Carbohydrate Catabolism
Glucose catabolism includes:
gycolysis, TCA cycle, and the pentose phosphate pathway
Carbohydrate Anabolism
Gluconeogenesis
synthesizing glucoses
Carbohydrate Anabolism
Photosynthesis
synthesizing glucoses
Carbohydrate Anabolism
Glycogenesis
Storage of glucoses in the form of polysaccharides
Lipid Catabolism
What is the name for Lipid Catabolism
Lipolysis
Lipid Catabolism
Tryglycerides split into ….
glycerol and fatty acids
Lipid Catabolism
Why is this done?
So muscles, liver, and adipose tissues can oxdize fatty acids
Lipid Anabolism
What is lipid anabolism called?
Lipogenesis
Lipid Anabolism
Which cells synthesis lipids?
Liver and adipose cells
Lipid Anabolism
What do they synthesis lipids from?
glucose or amino acids
Lipid Anabolism
Why does lipogenesis occur?
When we consume more calories than needed for ATP production