ch. 16 contd

Question 1

Example of T- or B- cell depeleting agents

Answer 1

Muromonab(OKT3); blocks CD3–> can’t activate T cells

Question 2

Example of autoimmune treatment that targets trafficking/adhesion

Answer 2

Fingolimod: S1PR agonist–> prevents T cells from leaving thymus

Question 3

Immunosuppressant that targets TCR signaling

Answer 3

cyclosporin A: inhibits release of inflammatory cytokines by deactivating transcription factors

Question 4

Immunosuppressant that targets cytokine signaling

Answer 4

Sirolimus; mTOR inhibitor, renal transplant rejection

Question 5

In specific immunosuppressant therapy, what is the role of OTK3?

Answer 5

mAb to CD3 of TCR depletes mature T cells prior to transplant via phagocytic cells binding to Ab coated T cells

Question 6

In specific immunosuppressant therapy, how is T-cell anergy induced?

Answer 6

blocking of T cell costimulation by soluble CTLA-4 fusion proteins can induce T-cell anergy