Ch 12 Part 1: B Cell Activation and Antibody Production Part 1 Flashcards
Activation of B cells is initiated by specific recognition of what by what
Antigens by surface BCRs
What helps stimulate the proliferation and differentiation of specific B cell clones?
Antigens and other stimuli including T helper cells
Progeny of the clone can do 4 things
1) become plasma cells that produce IgM
2) isotype switch
3) undergo affinity maturation
4) become memory cells
A single B cell may give rise to as many as ___ Ab-secreting cells per week
5000
At the peak of the humoral immune response about how many abs molecules are produced every day?
10^12
The ____ and amount of __ produced determines the immune respons
Type and amount of antibodies (concentration of antibodies)
In secondary lymphoid tissues, follicular B cells migrate into the _____ of these tissues called ____
B cell zones called follicles
Movement of B cells into lymphoid follicles is guided by chemokine ____ secreted by ___
CXCL13 secreted by follicular DCs
Follicular DCs express complement receptor called what and present antigens in complexes to what cells
CR2 and present to follicular B cells
In the spleen Ags in immune complexes may bind to __ complement receptors on ____
CR2 in marginal zone B cells
Follicular B cell survival depends on signals from the __ and inputs received from cytokine called ___
BCR and BAFF
-Baff provides maturation and survival signals through baff receptor
BAFF is produced by ___ in lymphoid follicles and in the bone marrow
myeloid cells (macrophages, dendritic cells)
Tfh cells express which 4 factors
ICOS, PD-1, Bcl-6, IL-21
___ is secreted by Tfh cells and it required for GC develiopment and generation of plasma cells
IL-21
Tfh cells also secrete __ and __ which control isotype switching
IL-4 and IFN-y
