Ch 10: Differentiation and Fnct of CD4+ T Cells Flashcards
1 in ____ T cells has a specific TCR that can recognize a given pathogen
10^6
a/b T cells express TCR and what?
CD4 or CD8 co-receptor
Activation of T cells is initiated by a signaling cascade after at least how many TCRs recognize specific Ag
2
What 3 things do you need from T cell to activate it
1) TCR
2) CD4 or CD8
3) CD3
Activation of macrophages elicits what 3 responses?
1) production of reactive oxygen species, nitric oxide, increased lysosomal enzymes
2) secretion of cytokines TNF, IL-1, IL-12, IL-23. chemokines (inflammation)
3) increased expression of B7 co-stimulators, MHC molecules
TNF, IL-1, chemokines secreted by macrophages function
leukocyte recruitment (inflammation)
Increased expression of B7 costimulators, MHC molecules by activated macrophages function
Increased T cell activation, amplification of T cell response
2 Functions of IL-4 and IL-13 secreted by TH2 helper cells
1) alternative macrophage activation (tissue repair) macrophages secrete IL-10 and TGF-B
- inhibits IFN-y macrophage response
2) Intestinal mucus secretion and peristalsis
IL-17 effects on leukocytes and tissue cells
TNF, IL-23, and CSFs secreted, which causes neutrophil rich inflammation
Nontraditional T cells
yd TCRs and CD3
no CD4 or CD8
abundant in intestine, uterus, tongue
first line defense, bridge btwn innate and adaptive response
yd T cells recognize presented or unpresented Ags?
unpresented
It has been postulated that yd T cells kill cells that become ____ as the result of a microbial infection
stressed
NKT cells share ___ and ___ of both T cells and NK cells
properties and CD markers
What do NKT cells recognize?
self and foreign lipids and glycolipids
lipids and glycolipds are presented within the non-polymorphic ___ molecule- Ag presentiing complex like MHC
CD1d
