Ch. 12 Flashcards
Mast cells
Connective tissue cells that contain heparin and histamine
Prophylactic management
Control of mild persistent asthma
Anti-LTS can be considered as an alternative agent
When ICS are not tolerated
Nonsteroidal
Cromolyn sodium
Zafirlukast
Montelukast
Zileuton
Omalizumab
Mechanisms of inflammation and asthma
Asthma is in inflammatory disorder of the airways, resulting in chronic persistent airway, inflammation and occasional acute episodes of wheezing and airway obstruction caused by bronchoconstriction, mucus, swelling, mucus, secretions, and vascular leakage
Allergy induced asthma
Extrinsic
Asthma induced locally without external factors
Intrinsic
T lymphocytes mediate the immune response by attracting mast cells and eosinophils
Which released mediators that attract other cells and damage epithelial cells
Inflammatory response manifests as
Vascular leakage, bronchoconstriction, mucus secretion, mucosal swelling
Cromolyn
(mast cell-stabilizing)
Agent
Inhibits mast cell degranulation
Clinical application of Cromolyn sodium
May take 2 to 4 weeks for improvement in patient symptoms
Antileukotriene agents
Leukotriene receptor antagonists
Omalizumab
-Parenteral administration
-Monoclonal antibodies
-Selectively be to human IgE, blocking IgE binding to mast cell receptors
-uncontrolled moderate to severe asthma
Nonsteroidal anti asthma agents
The agents discuss should not be considered for uncontrolled patients and active respiratory distress
