Ch 11: Circulatory System & Q bank Flashcards
The heart has three major layers:
(1) the inner endocardium of endothelium and subendothelial connective tissue;
(2) the myocardium of cardiac muscle; and
(3) the epicardium, connective tissue with many adipocytes and covered by mesothelium.
The cardiac conducting system stimulates rhythmic contractions and consists of modified cardiac muscle fibers forming
the sinoatrial (SA) and atrioventricular (AV) nodes,
the atrioventricular bundle (of His), left and right bundle branches,
and Purkinje fibers.
Purkinje fibers, located just beneath the endocardium of both ventricles, are:
distinguished from contractile fibers by their greater diameter, abundant glycogen, and more sparse bundles of myofibrils.
Masses of dense irregular connective tissue make up the cardiac skeleton, which surrounds…
the bases of all heart valves, separates the atria from the ventricles, and provides insertions for cardiac muscle.
VASCULATURE:
Macroscopically visible blood vessels have three major layers or Tunics.
(1) The intima includes the endothelium, connective tissue, and an internal elastic lamina in larger vessels; (2) the media contains alternating layers of smooth muscle and collagen or elastic lamellae; and (3) the adventitia (or externa) contains connective tissue, small vessels (vasa vasorum), and nerves.
VASCULATURE:
Through the vasculature, endothelial cells are not simply heart and vessel liners, they also do……
actively produce factors that prevent blood clotting,
factors that cause adjacent smooth muscle cells to contract or relax, and
factors that initiate inflammation at sites of damage or infection.
VASCULATURE:
Arteries are grouped by size and wall composition:
(1) large elastic arteries, with fenestrated elastic laminae in the thick tunica media; (2) muscular, medium-sized arteries; and (3) small arteries, with fewer than 10 layers of smooth muscle in the media.
VASCULATURE:
A microvasculature too small for surgical manipulation permeates most organs and consists of
(1) arterioles, with one to three smooth muscle layers;
(2) capillaries, consisting only of an intima endothelial layer; and
(3) venules, with large lumens and thin walls, which drain capillaries.
VASCULATURE:
Terminal arterioles branch into metarterioles, in which smooth muscle sphincters contract to resist blood flow and
relax cyclically to allow pulsatile flow of blood into an anastomosing capillary bed, where metabolic exchange with surrounding cells occurs.
VASCULATURE:
Capillaries are classified as three structural and functional types, with features that allow different degrees of molecular or even cellular exchange:
3 kinds
(1) continuous capillaries with many tight junctions so that all exchange must occur through the cells;
(2) fenestrated capillaries with small pores or fenestrations through the cells; and
(3) discontinuous capillaries, or sinusoids, with larger lumens, large spaces between the endothelial cells, and a discontinuous basal lamina.
VASCULATURE:
Capillary beds generally drain into venules, the last segment of the microvasculature; HERE, THEIR LIES……
postcapillary venules are the sites at which white blood cells enter damaged or infected tissues.
VASCULATURE:
The endothelium of continuous capillaries and postcapillary venules is frequently surrounded by thin cells called
pericytes, whose contractions facilitate blood flow and which can give rise to smooth muscle and connective tissue during microvascular remodeling or repair.
VASCULATURE:
Two alternative microvascular pathways include:
arteriovenous anastomoses, or AV shunts, in which arterioles can bypass a capillary bed, and
venous portal systems, in which venules draining a capillary bed quickly branch again to form another capillary bed.
VASCULATURE:
Small, medium, and large veins, all with lumen diameters exceeding the thickness of the wall, carry blood back to the heart, with…
intimal valves preventing backflow, and have increasingly well-developed tunics.
LYMPHATIC VESSELS:
Interstitial fluid that is not pulled into venules by colloidal osmotic pressure drains……
as lymph into blind vessels called lymphatics, or lymphatic capillaries, which have very thin endothelial cell walls with spaces between the cells.
LYMPHATIC VESSELS:
Lymphatics converge into larger, thin-walled lymphatic vessels in which
lymph is propelled by movements of surrounding muscles and organs, with intimal valves keeping the flow unidirectional.
LYMPHATIC VESSELS:
The largest lymphatic vessels, the thoracic duct and right lymphatic duct, both with walls having tunics like those of veins…
return lymph to the circulatory system by joining veins near the heart.
Vasa vasorum serve a function analogous to that of which of the following?
a. Valves
b. Basal lamina
c. Coronary arteries
d. Endothelial diaphragms
e. Arterioles
What tissue is directly associated with and extends into the heart valves?
a. Myocardium
b. Epicardium
c. Atrioventricular bundle of His
d. Cardiac skeleton
e. Pericardium
Which of the following is true for ventricles?
a. Located at the base of the heart
b. Myocardial cells contains abundant granules
c. Receive blood directly from the venae cavae and pulmonary veins
d. Walls contain Purkinje fibers of the right and left branches from the atrioventricular bundle
e. Contain more elastic fibers than the atria
Individuals with Marfan syndrome have mutations in the fibrillin gene and commonly experience aortic aneurisms. What portion of the arterial wall is most likely to be affected by the malformed fibrillin?
a. Endothelium
b. Tunica intima
c. Tunica media
d. Tunica adventitia
e. Vasa vasorum
Which description is true of continuous capillaries?
a. Unusually wide lumens
b. Most common in both brain and muscle
c. Abundant fenestrations
d. Lack a complete basement membrane
Which of the following is true of pericytes?
a. Are associated with the basal lamina of capillary endothelial cells
b. Have similar histological features as contractile cells of the myocardium
c. Form a layer of cells joined by gap junctions
d. Are terminally differentiated
e. Capable of forming multinucleated muscle fibers
During light microscopic examination of a tissue, you note a vessel that has no smooth muscle but a large amount of connective tissue at its periphery. Which of the following vessels are you examining?
a. Arteriole
b. Venule
c. Elastic artery
d. Capillary
e. Large vein
