ch 11 Flashcards
study of drugs that alter processes controlled by the nervous system
Neuropharmacology
the process of conducting an action potential down the axon of the neuron
axonal conduction
the process by which information is carried across the gap between the neuron and the postsynaptic cell
synaptic transmission
axonal conduction
synaptic transmission
which is selective and which is non-selective
axonal conduction is non-selective
synaptic transmission is selective
most neuropharmacological agents act by
altering synaptic transmission
the effect of a drug on a neuronally regulated process is dependent on
the ability of that drug to directly or indirectly influence receptor activity on target cells
what are the 5 steps in synaptic transmission
1) Transmitter synthesis
They can either increase transmitter synthesis, decrease transmitter synthesis, or cause the synthesis of transmitter molecules that are more effective than the natural transmitter itself.
2)Transmitter storage
3) Transmitter Release
Promote or inhibit transmitter release
4) Receptor Binding
They can either bind to receptors to cause activation, bind to receptors and block receptor activation by other agent or bind to receptor components and thereby enhance receptor activation by the natural transmitter at the site
5) Termination of transmission
They can either (reuptake, enzymatic degradation and diffusion)
drugs that directly activate receptors
agonists
drugs that prevent receptor activation
antagonists
the more types of receptors we have to work with, the greater our chances of producing
selective drug effects
most prominent responses to B1 receptors are
increased HR
increased force of contraction
most prominent responses to B2 receptors
bronchial dilation
elevation of blood glucose levels
