Ch 11 Flashcards
How do neuropharmacologist drugs modify body processes?
By mimicking or blocking neuronal regulation
Types of postsynaptic cell
Neuron muscle cell or cell within secretory gland
What are the two steps by which neurons influence the behaviors of the postsynaptic cell?
Axonal conduction
Synaptic transmission
The process of conducting an actions potential down the axon of a neuron
Axonal conduction
Process by which information is carried across gap between neuron and postsynaptic cell
Synaptic transmission
What two neuronal activities can a drug alter to influence a process under neuronal control
Axonal conduction
Synaptic transmission
Type of drugs that alter axonal conduction?
Are these specific or not?
Local anesthetic
Not specific
The effects of neuropharmacologic drugs depend on what?
Ability of the drug to directly or indirectly influence receptor activity on target cells
What is receptor activation mean
Effect on receptor to function equivalent to that produced by the natural neurotransmitter at particular synapse
Name the three effects drugs have on transmitter synthesis
1- increase transmitter synthesis
2-decrease transmitter synthesis
3- cause the synthesis of transmitter molecules that are more effective than the natural transmitter itself
What is “super”
Transmitter
Molecules that ability to activate receptors is greater than that of the naturally occurring transmitter at a particular site
True or false
Drugs that interfere with transmitter storage will cause receptor activation to increase
False
They will decrease because disruption of storage depletes vesicles of their context thus decreasing amount of transmitter available for release
How do drugs act directly at receptors
1- bond to receptor and activate
2- bind to receptor and black receptor activation by other agents
3- mins to receptor components and enhance receptor activation by the natural transmitter at the site
What are agonists
Drugs that directly activate receptors
What are antagonists
Drugs that prevent receptor activation
How do drugs interfere with termination of transmitter action
1- blockade of transmitter reputable
2- inhibition of transmitter degradation
True or false
Drugs that interfere with termination of transmitter action increase transmitter availability
True
Receptor activation is increased
What are the 3 components you need to know to understand any particular PNS drug
1- the type of receptor through which the drug acts
2- the normal response to activation of receptors
3- does the drug in question increase or decrease receptor activation
What is the most prominent response of activation of B1 adrenergic receptors
Increased heart rate and increased force of contraction
Primary response of activation of b2 adrenergic receptors
Bronchial dilation and elevated blood glucose