Ch 11

Question 1

How do neuropharmacologist drugs modify body processes?

Answer 1

By mimicking or blocking neuronal regulation

Question 2

Types of postsynaptic cell

Answer 2

Neuron muscle cell or cell within secretory gland

Question 3

What are the two steps by which neurons influence the behaviors of the postsynaptic cell?

Answer 3

Axonal conduction

Synaptic transmission

Question 4

The process of conducting an actions potential down the axon of a neuron

Answer 4

Axonal conduction

Question 5

Process by which information is carried across gap between neuron and postsynaptic cell

Answer 5

Synaptic transmission

Question 6

What two neuronal activities can a drug alter to influence a process under neuronal control

Answer 6

Axonal conduction

Synaptic transmission

Question 7

Type of drugs that alter axonal conduction?

Are these specific or not?

Answer 7

Local anesthetic

Not specific

Question 8

The effects of neuropharmacologic drugs depend on what?

Answer 8

Ability of the drug to directly or indirectly influence receptor activity on target cells

Question 9

What is receptor activation mean

Answer 9

Effect on receptor to function equivalent to that produced by the natural neurotransmitter at particular synapse

Question 10

Name the three effects drugs have on transmitter synthesis

Answer 10

1- increase transmitter synthesis
2-decrease transmitter synthesis
3- cause the synthesis of transmitter molecules that are more effective than the natural transmitter itself

Question 11

What is “super”

Transmitter

Answer 11

Molecules that ability to activate receptors is greater than that of the naturally occurring transmitter at a particular site

Question 12

True or false

Drugs that interfere with transmitter storage will cause receptor activation to increase

Answer 12

False
They will decrease because disruption of storage depletes vesicles of their context thus decreasing amount of transmitter available for release

Question 13

How do drugs act directly at receptors

Answer 13

1- bond to receptor and activate
2- bind to receptor and black receptor activation by other agents
3- mins to receptor components and enhance receptor activation by the natural transmitter at the site

Question 14

What are agonists

Answer 14

Drugs that directly activate receptors

Question 15

What are antagonists

Answer 15

Drugs that prevent receptor activation

Question 16

How do drugs interfere with termination of transmitter action

Answer 16

1- blockade of transmitter reputable

2- inhibition of transmitter degradation

Question 17

True or false

Drugs that interfere with termination of transmitter action increase transmitter availability

Answer 17

True

Receptor activation is increased

Question 18

What are the 3 components you need to know to understand any particular PNS drug

Answer 18

1- the type of receptor through which the drug acts
2- the normal response to activation of receptors
3- does the drug in question increase or decrease receptor activation

Question 19

What is the most prominent response of activation of B1 adrenergic receptors

Answer 19

Increased heart rate and increased force of contraction

Question 20

Primary response of activation of b2 adrenergic receptors

Answer 20

Bronchial dilation and elevated blood glucose