Ch 10: Blood Vessels

Question 1

Immune mechanisms involved in vasculitis

Answer 1

1) deposition of immune complexes 2) direct attack on vessels by circulating Ab 3) Various forms of cell-mediated immunity

Question 2

p-ANCAs are mainly against what ag?

Answer 2

MPO (myeloperoxidase)

Question 3

c-ANCAs are mainly against what ag?

Answer 3

PR3 (proteinase 3)

Question 4

Acute phase: Endothelial injury and denudation, ballooning degeneration of intimal smooth muscle cells & macrophages & medial smooth muscle cell necrosis, which may be fibrinoid.
Chronic phase: intimal hyperplasia and fibrosis of the vessel wall. Occasionally, vessels show complete fibrous occlusion.

Answer 4

Radiation Vasculitis

Question 5

What are the Large vessel vasculitis diseases?

Answer 5

Giant Cell (temporal) Arteritis
Takayasu Arteritis

Question 6

What are the medium vessel vasculitis diseases?

Answer 6

Polyarteritis Nodosa

Kawasaki Disease

Question 7

What are the small vessel vasculitis diseases?

Answer 7

Microscopic Polyangitis
Granulomatosis w/ Polyangitis (Wegener’s)
Eosinophilic Granulomatosis w/ Polyangitis (Churg Strauss)
IgA Vasculitis (Henoch-Schonlein)

Question 8

ANCA associated with Granulomatosis w/ Polyangitis (Wegener’s)

Answer 8

c-ANCA

Question 9

ANCA associated with Microscopic Polyangitis

Answer 9

p-ANCA

Question 10

ANCA associated with Eosinophilic Granulomatosis w/ Polyangitis (Churg-Strauss)

Answer 10

p-ANCA

Question 11

Classic findings seen in Granulomatosis w/ Polyangitis

Answer 11

Sinusitis, hemoptysis w/ bilateral lung infiltrates, hematuria due to progressive glomerulonephritis

Question 12

Classic findings seen in IgA Vasculitis (Henoch-Schonlen Purpura)

Answer 12

Palpable purpura on the buttocks and legs, GI Pain, hematuria (IgA Nephroathy)

Question 13

Classic findings seen in Thromboangitis Obliterans (Buerger Disease)

Answer 13

Ulceration, gangrene and autoamputation of fingers and toes, Raynaud phenomenon is often present

Question 14

Classic findings seen in Kawasaki Disease

Answer 14

Non-specific signs: fever, conjunctivitis, erythematous rash of palms and soles and enlarged cervical lymph nodes

Question 15

Classic findings seen in Polyarteritis Nodosa

Answer 15

Seen in young adults w/ hypertension, abdominal pain w/ melena, neurologic disturbances and skin lesions

Question 16

Classic findings seen in Eosinophilic Granulomatosis w/ Polyangitis (Churg- Strauss)

Answer 16

Asthama & peripheral eosinophilia

Question 17

Classic Findings seen in Microscopic Polyangitis

Answer 17

NO nasopharyngeal involvement of granulomas (differentiates from Wegeners)

Hemoptysis w/ bi-lateral lung infiltrates, hematuria due to progressive glomerulonephritis

Question 18

Classic Findings seen in Takayasu Arteritis

Answer 18

Present in adults ) in the upper extremity, ESR is elevated