CH 1 Arthritic/skeletal/soft tissue conditions Flashcards
DJD/OA is characterized by
degeneration of articular cartilage, with hypertrophy of subchondral bone and joint capsule of weight bearing joints
Medications for OA:
cortiscosteroids, NSAIDS; Glucocorticoids are injected in to joints that are inflamed and not responsive to NSAIDS
Diagnostic tests reveal what for DJD/OA
diminished point space, decreased height of articular cartilage and osteophytes
What is ankylosing Spondylitis
progressive inflammatory disorder of unknown etiology
Ankylosing Spondylitis begins in the
axial skeleton
The initial onset of ankylosing spondylitis is typically in what decade of life
before the fourth decade
First symptoms of ankylosing spondylitis
mid and low back pain, morning stiffness and sacroiliitis
Advanced ankylosing spondylitis is characterized by
degeneration of peripheral and costovertebral joints
ankylosing spondylitis effects ___ 3x more than __
men, women
2 drugs besides NSAIDS/corticosteroids for ankylosing spondylitis
Cytotoxic drugs - block cell growth and Tumor necrosis factor inhibitors
Diagnostic test for ankylosing spondylitis:
HLA-B27
What is Gout
genetic disorder of purine metabolism characterized by elevated serum uric acid
Where is gout most frequently observed
knee and great toe
Specific NSAID for gout
indomethacin
Diagnostic test for gout
lab tests identify monosodium rate crystals in synovial fluid or connective tissue samples