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Pathology: Diseases Of The Female Genital tract > Cervix > Flashcards

Cervix Flashcards

1
Q

Diseases in the cervix

A

Endocervical Polyps
CIN
Cervical Cancer

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2
Q

Cause of endocervical polyps

A

Irregular vaginal bleeding/post coitus

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3
Q

Histological Findings of Endocervical Polyps

A

Fibromyxoid stroma
Endocervical epithelium
Inflammation

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4
Q

High risk HPV in developing cervical cancer

A

HPV 16- 60%

HPV18- 30%

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5
Q

How does HPV E7 contribute to cell proliferation

A

Inactivation Rb, p21 and p27

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6
Q

How does HPV E6 contribute to cellular immortality

A

P53 inactivation and activation of telomerase

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7
Q

Cancer confined to the epithelium

A

Cervical Intraepithelial Neoplasm

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8
Q

Most important risk factor in developing cervical cancer

A

HPV
16 (60%)
18 (10%)

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9
Q

Premalignant lesion classification of CIN

A

HSIL

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10
Q

Recite table of classification

A

Page 108

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11
Q

Morphologic pearls of CIN

A

Koilocytic Atypia

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12
Q

Expansion of immature cell from basal layer

A

Grade

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13
Q

Upper 2/3 of the epithelium

A

HSIL

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14
Q

Lower third of epithelium

A

LSIL

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15
Q

> 80% of LSIL and 100% of HSIL are associated to what HPV

A

HPV 16

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16
Q

Most ___ regress

A

LSIL

17
Q

10% persist to carcinoma in 2 to 10 years

A

HSIL

18
Q

10% progress to HSIL

A

LSIL

19
Q

Cervical cancer generalities (3)

A

CIN plus invasion beyond basement membrane
80%- squamous 15%- adenocarcinom adenosquamous and neuroendocrine (5%)
Most common cause of death: Uremia (Kidney invasion stage III)

20
Q

Most common cause of death of cervical cancer

A

Uremia

21
Q

Screening of cervical cancer

A

Papanicolou Smear

21 or within 3 years of first coitus, every 3 years until 30
If beyond 30 and negative every 5 years but if HPV infection every 6-12 months

22
Q

If positive for papsmear

A

Colposcopy with VIA

Schiller Test with VILI

23
Q

Age na pede ivaccinate yung at risk for cervical camcer

A

11-12 until 26

24
Q

Vaccines for cervical cancer

A

Cervarix (HPV 16 and 18)

Gardasil (6 11 16 18)

25
Q

How long does protection last from cervical vaccines

A

10 years

26
Q

Break muna

A

Break muna

Pathology: Diseases Of The Female Genital tract (8 decks)

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