Cervix Flashcards
Diseases in the cervix
Endocervical Polyps
CIN
Cervical Cancer
Cause of endocervical polyps
Irregular vaginal bleeding/post coitus
Histological Findings of Endocervical Polyps
Fibromyxoid stroma
Endocervical epithelium
Inflammation
High risk HPV in developing cervical cancer
HPV 16- 60%
HPV18- 30%
How does HPV E7 contribute to cell proliferation
Inactivation Rb, p21 and p27
How does HPV E6 contribute to cellular immortality
P53 inactivation and activation of telomerase
Cancer confined to the epithelium
Cervical Intraepithelial Neoplasm
Most important risk factor in developing cervical cancer
HPV
16 (60%)
18 (10%)
Premalignant lesion classification of CIN
HSIL
Recite table of classification
Page 108
Morphologic pearls of CIN
Koilocytic Atypia
Expansion of immature cell from basal layer
Grade
Upper 2/3 of the epithelium
HSIL
Lower third of epithelium
LSIL
> 80% of LSIL and 100% of HSIL are associated to what HPV
HPV 16
Most ___ regress
LSIL
10% persist to carcinoma in 2 to 10 years
HSIL
10% progress to HSIL
LSIL
Cervical cancer generalities (3)
CIN plus invasion beyond basement membrane
80%- squamous 15%- adenocarcinom adenosquamous and neuroendocrine (5%)
Most common cause of death: Uremia (Kidney invasion stage III)
Most common cause of death of cervical cancer
Uremia
Screening of cervical cancer
Papanicolou Smear
21 or within 3 years of first coitus, every 3 years until 30
If beyond 30 and negative every 5 years but if HPV infection every 6-12 months
If positive for papsmear
Colposcopy with VIA
Schiller Test with VILI
Age na pede ivaccinate yung at risk for cervical camcer
11-12 until 26
Vaccines for cervical cancer
Cervarix (HPV 16 and 18)
Gardasil (6 11 16 18)
How long does protection last from cervical vaccines
10 years
Break muna
Break muna
