Cervical HPV CPC

Question 1

With regards to cervical cancer, HPV is…

Answer 1

Necessary, but not sufficient.

Question 2

What are 4 risk factors for cervical carcinoma other than HPV infection? (2 are likely surrogates for HPV infection)

Answer 2

Multiple sexual partners: >6
Early age of first sexual intercourse.
Cigarette smoking.
Immunosuppression.

Question 3

Do you have to have to have penetrative intercourse to contract HPV?

Answer 3

Apparently not. Can probably be spread by hands, any sort of contact.

Question 4

3 outcomes of Squamous Intraepithelial Lesions (SIL)?

Answer 4

Regress, persist, progress (to carcinoma)

Question 5

What do you do if Pap smear yields ASC-US in a woman over age 25?

Answer 5

Reflex HPV testing.

Question 6

Cotesting can allow you space out testing intervals to every 5 years… in some cases, depending on the algorithm flow chart blah blah blah.

Answer 6

Yep.

Question 7

Which HPV genotype is the most carcinogenic?

Answer 7

HPV 16

HPV 18 is a little less so

Question 8

Do HPV infections (or at least the lesions thereof) sometimes clear?

Answer 8

Yep. And you can wait for that to happen before treating aggressively.

Question 9

What cancer does Pap smears fail to screen for?

Answer 9

Adenocarcinoma.

Question 10

What percentages of women with cervical cancer in the US have never had a Pap smear / not had one in the past 5 years?

Answer 10

50% have never had one.

10% not in the past 5 years.

Question 11

What can you use to see evidence of transformation during colposcopy (not histology)?

Answer 11

Acetic acid -> causes transformed areas to turn white.

Question 12

Will continue this when we have a better sense of what’s going to be testable from the CPCs.

Answer 12

Sounds grand.