Cervical CPC Flashcards

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ASC-US

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6
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7
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Cervical cancer

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8
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9
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10
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16
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18
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HSIL / CIN3

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20
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LSIL / CIN1

21
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Microinvasion

22
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Normal or abnormal?

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Normal

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26
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Transformation zone

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31
Q

What strains of HPV does the 2006 vaccine protect against?

A

6, 11, 16, 18

32
Q

What are the functions of the E6 viral protein?

A
  • interrupt cell death pathways by binding p53
  • induce centrosome duplication, genomic instability
  • upregulate telomerase
33
Q

What are the functions of the E7 viral protein?

A
  • disrupt cell cycle by RB binding with upregulation of cyclin E and p16INK4
  • induce centrosome duplication, genomic instability
34
Q

What does CIN stand for?

A

Cervical interepithelial neoplasm