Cerebellum Flashcards

1
Q

Cerebellum is also called what?

A

Little brain

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2
Q

The layers of the cerebellum. (slide info)

A
  • lots of folds to increasse surface area
  • not every cell type is restricted completely to one layer
  • some have processes that extend across multiple layers
  • permits dispersion of inputs across multiple layers and cell types
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3
Q

Purkinje cells

A

only cells whose axons project information OUT from the cerebellum

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4
Q

What are the main lobes of the cerebellum?

A
  • anterior (superior)
  • flocculondular (middle)
  • posterior (most of it)
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5
Q

What are the main structures of the cerebellum? as well the colors associated in the pictue?

A
  • Flocculus (blue)
  • Nodule (orange)
  • Paravermis (green)
  • Vermis (yellow spine)
  • Cerebellar Tonsils (pink)
  • Cerebellar Peduncles (brown)
  • Hemisphere
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6
Q

What are the cerebellar peduncles and where do they go?

A
  • superior (midbrian and pons)
  • middle (pons)
  • inferior (medulla and pons
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7
Q

What is the dentate nucleus?

A

connections with thalamus, olive, cortex, sensory and motor pathways

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8
Q

what are the interposed nuclei?

A

Emboliform and globose nucleus
conenctions with thalamus and red nucleus

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9
Q

what is the fastigial nucleus?

A

connections with thalamus, spinal cord, vestibular organ

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10
Q

What are the primary “known” functions of the cerebellum?

A
  • Motor planning, motor learning, and motor control
  • Control of posture and balance
  • Coordination of smooth voluntary movements in terms of:
    • accuracy, force, amplitude, speed, direction
  • Vision & Vestibular
  • Speech
  • Mood
  • Cognition
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11
Q

What is the main efferent tract that originates form the cerebellum?

A

vestibulospinal

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12
Q

What is the main efferent tract that is influenced by the cerebellum?

A

corticospinal

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13
Q

What is the main afferent tract that is ending in the cerebellum?

A

spinocerebellar

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14
Q

what is the functional areas of the spinocerebellum?

A

anterior lobe, vermis and paravermis

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15
Q

What is the main functional areas of the vestibulocerebellum?

A

flocculus and nodule

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16
Q

What is the functional area for the cerebrocerebellum?

A

most of the posterior lobe

17
Q

What is the function of the spinocerebellum?

A
  • inputs from spinocerebellar tract, dorsal column medial lemnisus tract, and trigeminal nerve nuclei
  • outputs to deep cerebellat nuclei to modulate motor tracts via cortex, thalamus and brainstem (red nucelus, reticular formation, and vestibular nerve nuclei)

Proprioception (sensory)
Proximal limb and trunk coordination (motor)

18
Q

What is the function of the cerebrocerebellum?

A
  • inputs from the cortex via the pons
  • outputs via dentate nucleus to red nucleus of midbrain and ventral lateral nucleus of thalamus
  • influences the corticospinal tract

motor planning of extremities
distal limb coordiantion

19
Q

what are the functions of the vestibulocerebellum?

A
  • inputs from vestibular nerve and superior colliculus
  • output to vestibular nuclei in brainstem
  • influences vestibulospinal tract

balance and postural control
vestibulo-ocular control

20
Q

Vascular supply of the cerebellum?

A

Posterior circulation:
Superior cerebellar artery
Anterior inferior cerebellar artery
Posterior inferior cerebellar artery

21
Q

what does the superior cerebellar arteries supply?

A
  • supplies spinocerebellum and parts of the cerebrocerebellum
  • anterior and superior
22
Q

What does the anterior inferior cerebellar arteries supply?

A
  • supplies vestibulocerebellum and parts of cerebrocerebellum
  • middle
  • floccules
23
Q

Whar does the posterior inferior and cerebellar arteries supply?

A
  • supplies parts of cerebrocerebellum
  • posterior inferior part of the cerebellum
24
Q

What is the etiology of cerebellum disorders?

A

Vascular (stroke), seizure, infection, inflammation, drugs, alcohol, genetic, tumor, trauma, psychogenic, unknown

25
Examples of cerebellum clincial disorders?
* Spinocerebellar ataxia * Friedrich’s ataxia * Ataxia with oculomotor apraxia (AOA Type I and II) * Cerebellar hypoplasia
26
What is ataxia?
incoordination
27
What is limb ataxia?
More common with LATERAL lesions of hemispheres Will be IPSILATERAL to lesion (pathway crosses at superior cerebellar peduncle and crosses again at medullary pyramids) (cerebrospinal) (upper and lower extremities)
28
What is trunk ataxia?
More common with MIDLINE lesions of vermis and/or flocculonodular lobe Will typically be BILATERAL because the trunk muscles work together.
29
What is gait ataxia?
More common with MIDLINE lesions of vermis and/or flocculonodular lobe Wide BOS, inconsistent foot placement, deviation from straight path (combination for both above.)
30
What is dysmetria?
Improper amplitude of movement Hypermetric = over-shooting target Hypometric = under-shooting target
31
What is intention/action tremor?
Involuntary movement that worsens during voluntary movement
32
What is dysdiadochokinesia?
inability to perform rapid alternating movements
33
What ate vestibular and ocular deficits
* Most commonly due to deficits of the flocculonodular lobe / vestibulocerebellum examples: * Nystagmus at rest * Gaze holding deficits * VOR cancellation deficits * Impaired saccades (hypermetric, hypometric) * Impaired smooth pursuit * Skew deviation * Vergence insufficiency
34
Why? Impared balance and postural control.
Balance is an integration of 3 systems: vision, proprioception, and vestibular To maintain postural control, need to choose appropriate amplitude/direction/speed/etc. of movement and then correct as needed
35
Damage to which functional area(s) will most likely impact balance/postural control?
Spinocerebellar tract, Cerebrocerebellar, ALL3
36
What is dysarthria?
difficulty with speech clarity due to impaired control of muscles for speech
37
Patients with ataxia will perform worse when? (3)
* speed * more degrees of freedom * one or more balance systems are compromised