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Test > Cephalosporins And Fosfomycin > Flashcards

Cephalosporins And Fosfomycin Flashcards

1
Q

Cephalosporins fall under what category of abx?

A

Bactericidal, Cell-wall synthesis inhibitors, beta-lactams

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2
Q

1st Gen cephalosporins are which drugs and cover which bugs?

A

Cephalexin (Keflex), cefadroxil, cefazolin (Ancef): mainly G+
-staph aureus

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3
Q

2nd gen cephalosporins include which drugs?

A

Cofaclor, cefuroxime, cefprozil, cefoxitin, cefotetane

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4
Q

3rd Gen Cephalosporins include which drugs?

A

Cefdnir, cefditoren, cefixime, cefpodoxime, ceftibutin, cefotaxmine, ceftazidime, ceftriaxone

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5
Q

4th Gen Cephalosporins include which drugs?

A

Cefepime

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6
Q

5th gen cephalosporins include which drugs?

A

Ceftaroline, ceftolozane

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7
Q

What is the main difference going from first gen cephalosporins to 5th gen?

A

1st gen has G+ coverage, as you go down you lose some G+ coverage, but gain G- coverage and CNS penetration. 5th gen has MRSA coverage

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8
Q

Which cephalosporin has MRSA coverage?

A

Ceftaroline

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9
Q

Which cephalosporins cover for ESBL?

A

Ceftazidime/Avibactam and ceftolozane/tazobactam

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10
Q

Do cephalosporins cover for enterococcus?

A

No

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11
Q

Which cephalosporins cover for pseudomonas?

A

Ceftazidime, cefepime, and ceftolozane/tazobactam

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12
Q

Ceftriaxone (3rd gen) is indicated for what?

A

Meningitis, STDs, UTI, CAP

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13
Q

Cefepime (4th gen) is given for what?

A

Pseudomonas, sepsis, pylo

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14
Q

Ceftolozane/Tazobactam (5th gen) covers for what?

A

ESBLs and pseudomonas, complicated UTIs and pylo

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15
Q

There is an FDA warning for which cephalosporin and what other drug?

A

Ceftriaxone (3rd gen) and calcium containing products (if both given IV).
-esp if under 28d old, then contraindicated. Can give sequentially w lots of flushing

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16
Q

Ceftaroline (5th gen) covers what?

A

MRSA, but not pseudomonas
-CAP, skin and soft tissue infections

17
Q

What class of abx is Fosfomycin?

A

Bactericidal, cell wall synthesis inhibitor

18
Q

What are the indications for fosfomycin?

A

UNCOMPLICATED cystitis in women: E. Coli, and E. Faecalis
COMPLICATED UTIs in men, prostatitis
- so G- enterococcus species

19
Q

What is the dosing for fosfomycin

A

UTI women: 3g po x1, very convenient

20
Q

What is the pregnancy category for fosfomycin?

A

Pregnancy category B

Test (13 decks)

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