cephalosporins and cell wall inhibitors

Question 1

vancomycin is what class of Abx

Answer 1

glycopeptide

Question 2

daptomycin is hwat class of Abx

Answer 2

cyclic lipopeptides

Question 3

cefazolin what class

Answer 3

1st gen cephalo

Question 4

cefazolin what route

Answer 4

iv

Question 5

cephalexin what class

Answer 5

1st gen cephalo

Question 6

cephalexin what route

Answer 6

oral

Question 7

cefuroxime what class

Answer 7

2nd gen cephalo

Question 8

ceftriaxone what class

Answer 8

3rd gen cephalo

Question 9

ceftriaxone what route

Answer 9

iv

Question 10

ceftazidime what class

Answer 10

3rd gen cephalo

Question 11

ceftazidime what route

Answer 11

iv

Question 12

cefepime what class

Answer 12

4th generation cephalo

Question 13

ceftaroline what class

Answer 13

5th gen cephalo

Question 14

as a class cephalosporins are not active against which organisms

Answer 14

enterococci and listeria

Question 15

1st gen cephalos are more active against what kind of organisms

Answer 15

GP

Question 16

later gen cephalos are more active against waht kind of organisms

Answer 16

GN

Question 17

cephalsospirin mechanism of action

Answer 17

bind PBPs and inhibit assembly of bacterial cell wall = bactericidal

Question 18

cefazolin spectrum

Answer 18

GP few weak GNR

Question 19

cephalosporin drug interaction

Answer 19

probenecid inhibits renal active tubular secretion

Question 20

cefotetan drug class

Answer 20

2nd gen cephalo

Question 21

cefoxitin drug class

Answer 21

2nd gen cephalo

Question 22

2nd gen cephalosporin spectrum

Answer 22

GP and somewhat expanded GNR coverage (lebsiella)

Question 23

which 3rd gen cephalsoporin has good CSF penetration

Answer 23

ceftriaxone

Question 24

which cephalo has good P aeruginosa coverage?

Answer 24

ceftazidime

Question 25

ceftaroline coverage

Answer 25

GNR and GPC includes MRSA

Question 26

ceftaroline toxicity

Answer 26

10% conver to positive direct coombs

Question 27

meropenem mechanism of action

Answer 27

binds to PBP which inhibits the assembly of the bacterial cell wall leading to bactericidal action

Question 28

meropenem coverage

Answer 28

GPC, GNR, anaerobes

Question 29

meropenem route

Answer 29

IV

Question 30

how is meropenem’s CSF penetration

Answer 30

good

Question 31

aztreonam drug class

Answer 31

monobactam

Question 32

aztreonam coverage

Answer 32

olg GNR

Question 33

vancomycin coverage

Answer 33

virtually all GPC

C diff

Question 34

vancomycin resistance arises how

Answer 34

develops in enterococci and MRSA by changing D-Ala to D-lactate

Question 35

daptomycin coverage

Answer 35

GPC

Question 36

daptomycin mechanism of action

Answer 36

binds to cell membrane, depolarizes cell which leads to inhibition of synthesis of protein, DNA and RNA, leading to cell death
doesn’t enter cytoplasm

Question 37

daptomycin route

Answer 37

IV

Question 38

dapto toxicity

Answer 38

myopathy