Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm > Antifungals > Flashcards

Antifungals Flashcards

1
Q

drug target of azoles

A

ergosterol in cell membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

drug target of polyenes

A

ergosterol in cell membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

drug target of echinocandins

A

cell wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

3 classes of anti-fungals

A

azoles, polyenes, echinocandins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

prototype of polyene class

A

amphotericin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

protoype of echinocandin calss

A

capsofungin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

mechanism of action of azoles

A

inhibit rate limiting step in ergosterol synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

azole drug/enzyme interaction

A

cyp450 inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

how is fluconazole metabolized/ eliminated

A

renal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

how are vori and itra conazole meatoblized

A

hepatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

how is fluconazoles Gi absorption and CNS penetration

A

excellent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

benefit of fluconazole relative to other azoles

A

least drug interactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

fluconazole spectrum

A

candida and mild crypto

no activity against molds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

how is itraconazole’s Gi absorption and CNS penetration

A

poor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

disadvantage of itraconazole

A

most drug interactions of azoles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is drug of choice for histoplasma

A

itraconazole

17
Q

itraconazole sepctrum

A

most yeasts, many molds, and most dimorphics

18
Q

how is voriconazole’s CNS and GI penetration

A

excellent

19
Q

what is drug of choice for aspergillosis

A

voriconazole

20
Q

what is drug of choice for zygomycosis

A

posconazole

21
Q

mechanism of action of polyenes

A

bind to ergosterols in cell membrane and form membrane channels w/ increased permeability

22
Q

how well does amphotericin B penetrate the CNS

A

poorly

23
Q

how does amphotericin cause renal toxicity

A

damage to distal tubular membrane leads to electrolyte wasting which leads to decreased GFR

24
Q

what is advantage of lipid based formulation of amphotericin B

A

decreased drug reactions

25
Q

echinocandin mechanism of action

A

inhibits B (1.3) glucan synthesis in fungal cell wall

26
Q

echinocandin spectrum

A

candida and aspergillus

27
Q

capsofungin route

A

IV

28
Q

how is capsofungin metabolized/cleared

A

hepatically

29
Q

caspofungin drug interactions

A

cyp450

Pharm (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions