Cephalosporins

Question 1

How does cephalosporins work ?

Answer 1

interferes with bacterial cell wall synthesis, have similar spectrum to penicillins
broad-spectrum + bactericidal

Question 2

Name first generation cephalosporins ?

Answer 2

cefalexin
cefadroxil (BD)
cefradine

Question 3

Name second generation cephalosporins ?

Answer 3

cefuroxime

cefaclor ( protracted skin reactions, especially in children)

Question 4

Name third generation cephalosporins ? parenteral admin

Answer 4

Cefixime ( orally active)
Ceftraxione ( OD, treats meningitis )
Cefotaxime ( treats meningitis)
Ceftazidime

Question 5

Name fifth generation cephalosporins ? parenteral admin

Answer 5

ceftaroline use in CAP and complicated skin and soft tissue infections

Question 6

Which generation of cephalosporins are more likely to cause antibiotic associated colitis ?

Answer 6

second and third generation

Question 7

If patient has immediate penicillin hypersensitivity, cephalosporin should be avoided, however if no alternative is available and it is essential to give cephalosporin which generations can be given ?

Answer 7

third generation or cefuroxime ( 2nd generation)