Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

IDIT Exam 3 - Pharmacology > Cephalosporins > Flashcards

Cephalosporins Flashcards

1
Q

Cephalosporins

A
  • Main mechanism same as PCNs

* Resistant to many PCNases (β-lactamases)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

1st Gen Cephalosporins (3)

A 
• Resist Staph PCNase
• Good against G+ and G- (PEcK)
1. Cefazolin
2. Cephalexin
3. Cefadroxil
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

2nd Gen Cephalosporins

A

• Less G+ and more G- (HNPEcK)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

PEcK

A

Proteus mirabilis, E. Coli, Klebsiella pneumoniae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

HNPEcK

A

H. influenza, Neisseria, Proteus mirabilis, E. Coli, Klebsiella pneumoniae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cefaclor

A
  • 2nd Gen Cephalosporin

* Associated w/sx of serum sickness (arthralgias, urticaria, glomerulonephritis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cefuroxime

A
  • 2nd Gen Cephalosporin

* Ever 12 hours - good for compliance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cefoxitin

A
  • 2nd Gen Cephalosporin

* Active vs Bacteriodes fragilis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Cefotetan

A
  • 2nd Gen Cephalosporin

* Caution: side chain antagonizes vitamin K → hypoprothrombinemia; must supplement w/Vitamin K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

3rd Gen Cephalosporins

A

• Much less G+ but much more G-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ceftriaxone

A
  • 3rd Gen Cephalosporin
  • Good activity vs meningitis
  • DO NOT USE < 3 months (→kernicterus) unless as a single dose for gonorrhoeae conjunctivitis
  • DO NOT USE w/Ca containing products < 28 days old (→ppt in lungs & kidney)
  • Can cause sludge (nausea, anorexia, epigastric distress, colic)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cefdinir

A
  • 3rd Gen Cephalosporin

* Can bind iron (decreases absorption and reddens feces in infants on high Fe formula)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Other 3rd Gen Cephalosporins (2)

A
  1. Cefotaxime

2. Cefpodoxime

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Ceftazidime

A
  • 3rd Gen Cephalosporin

* Neurologic side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Cefepime

A
  • 4th Gen Cephalosporin
  • For G- rods resistant to 3rd gen
  • Neurological side effects
  • Mostly renal excretion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Cefditoren

A
  • 4th Gen Cephalosporin

* PRO-DRUG: Hydrolyzed by esterase’s during absorption

17
Q

Ceftaroline

A
  • Advanced generation Cephalosporin
  • Good for community acquired bacterial pneumonia, skin infections and MRSA
  • Side effects: nausea, diarrhea, rash
18
Q

General side effects for all Cephalosporin

A
  1. Hypersensitivity (risk of cross-allergy w/PCN > 1st gen)
  2. Nephrotoxicity
  3. Risk of immune-mediate hemolytic anemia

IDIT Exam 3 - Pharmacology (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions