Central Nervous System Flashcards

(94 cards)

1
Q

Definition of Seizure

A

Abnormal or uncontrolled neuronal discharges in the brain

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2
Q

Defintion of Convulsion

A

“involuntary violent spasm of large muscles of face, neck, arms or legs.

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3
Q

Definition of Eclampsia.

A

“severe hypertensive disorder of pregnancy characterized by seizures, com, and perinatal mortality.”

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4
Q

Epilepsy is

A

when someone has Chronic seizures.

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5
Q

An involuntary violent spasm of large muscles of face, neck, arms, and legs is a ________.

A

Convulsion

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6
Q

An Abnormal or uncontrolled neuronal discharges in the brain is a ____________.

A

Seizure.

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7
Q

severe hypertensive disorder of pregnancy, characterized by seizures, coma, and perinatal mortality is the definition of ________.

A

Eclampsia.

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8
Q

Difference between simple and complex partial (focal) epileptic seizures

A

simple= Olfactory and visual hallucinations, intense emotions, twitching of arms, legs and face;

Complex = Preceding aura and postictal confusion, no response to verbal comands.

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9
Q

Difference between Absense, Atonic, and Tonic-Clonic seizures

A

Absence (petit mal)
• Lasting a few seconds
• Seen most often in children (child stares into space, does not respond to verbal stimulation, may have fluttering eyelids or jerking)
• Misdiagnosed often (especially in child) as ADD or daydreaming

Atonic (drop attacks)
• Falling or stumbling for no reason
• Lasting a few seconds

Tonic-clonic (grand mal)
• Preceeded by aura
• Intense muscle contraction (tonic phase) followed by alternating contraction and relaxation of muscles (clonic phase)
• Crying at beginning as air leaves lungs; loss of bowel/bladder control; shallow breathing with periods of apnea; usually lasting 1–2 minutes

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10
Q

disorientation after a seizure is called

A

postictal state

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11
Q

myoclonic seizures are:

A

large jerking movements of a major muscle group. Think: myo (single muscle) and clonic (like grand mal/tonic-clonic.)

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12
Q

status epilepticus seizures are:

A

a medical emergecy, they are continuous seizue activity which can lead to coma and death.

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13
Q

True or False: Tonic Clonic Seizures are such a bad problem, that doctors usually start the pts on large doses of meds to make them go away fast.

A

False. The meds have really bad side effects (suidical thoughts/tendencies)and so they are usually put on a very small dose and titer up to a workable value over the course of like a month. It takes a while.

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14
Q

Three possible MOAs of seizure medications

A
  1. Stimulating an influx of Cl ions; 2. delaying influx of Na+; and 3. Delaying an influx of Ca2+ ions
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15
Q

True or False: Seizure Meds that work with Na+ ions blocks the channels

A

False. They just desensitize them.

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16
Q

What’s a side effect you’re going to want to look out for teens on this medication (and adults, too)?

A

Suicidal behavior. (This is prevalent in adults, too, of course, but adults also have problems with kidney/liver failure. teens are already super hormonal/anxty… so it’s pertinent to watch for suidical tendencies even more closely.)

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17
Q

Patient teaching of Barbituates and Gaba Agents

A
  • Use reliable contraception
  • Immediately report pregnancy
  • Report excessive signs of bleeding
  • Report drowsiness and bone pain
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18
Q

Drugs that potentiate the gaba action include:

A

Barbiturates, Benzodiazepines, Miscellaneous GABA agents

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19
Q

Hydantoins are used to treat what forms for epilepsy?

A

All forms except absence seizures

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20
Q

Phenytoin related drugs are used to treat what types of seizures?

A

Absence Seizures

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21
Q

True or False. If the pt hasn’t had a seizure in 2 years, they can stop taking the medication.

A

False. If they are free after 3 years, they can start taking less of their medication. Then if after taking less of their medication they are still taking less of their medication, they are still seizure free, they can take even, less… etc etc. Resume if seizures resume.

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22
Q

Pts coming off of seizure meds should be aware of

A

rebound seizure

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23
Q

Parkinsons disease is a progressive ______ of dopamine.

A

loss.

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24
Q

Symptoms known as Parkinsonism include:

A
	Tremors
	Muscle rigidity
	Bradykinesia
	Postural instability
	Affective flattening
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25
Drug Therapy for Parkinsonism
 Restores dopamine function  Blocks acetylcholine  Extrapyramidal side effects (EPS)
26
ROLE OF THE NURSE: | DOPAMINERGIC DRUG THERAPY
* Contraindicated in narrow-angle glaucoma * Monitor for hypotension and tachycardia * Look for symptoms of drug toxicity
27
DOPAMINERGICS CLIENT TEACHING
* Increase fiber and fluids * Avoid food and drugs high in pyridoxine * May take several months for full effect * Abruptly stopping the drug may cause Parkinsonism crisis
28
ANTICHOLINERGICS CLIENT TEACHING
* Relieve dry mouth with frequent drinks or sugarless hard candy * Take with food or milk to prevent GI upset * Avoid alcohol * Wear dark glasses; avoid bright sunlight * Do not stop taking abruptly
29
NURSING CONSIDERATIONS WITH | ACHE INHIBITORS
* Assess baseline vitals * Monitor for hypotension * Monitor for change in mental status or mood * Monitor for dizziness, insomnia, anorexia * Clients with narrow-angle glaucoma should not take revastigmine (Exelon)
30
* Assess baseline vitals * Monitor for hypotension * Monitor for change in mental status or mood * Monitor for dizziness, insomnia, anorexia * Clients with narrow-angle glaucoma should not take revastigmine (Exelon)
• Take with food or milk to avoid GI upset • Take as prescribed • Teach signs and symptoms of overdose o Severe nausea/vomiting, sweating, salivation, hypotension o Bradycardia, convulsions, increased muscle weaknesses (including respiratory muscles)
31
True or False: Some drugs are more effective than others.
False. All of these drugs have equal efficacy.
32
ANTIPARKINSONISM AGENTS
• Restore balance of dopamine and acetylcholine in brain
33
Possible causes of Alzheimers Disease
 Genetic defects  Chronic inflammation  Excess free radicals  Environmental factors but really it's unknown...
34
Structural Damage in Brain consist of
 Amyloid plaques |  Neurofibrillary tangles
35
 Symptoms of Alzheimers result from progressive damage to neurons in the _____ of the brain, which requires ______ as a neurotransmitter
hippocampus, acetylcholine
36
Symptoms of Alzheimer’s Disease
 Impaired memory and judgment  Confusion and disorientation  Inability to recognize family and friends  Aggressive behavior  Depression  Psychoses, including paranoia and delusions  Anxiety
37
MOA of Barbiturates
changing the action of GABA
38
MOA of Hydantoins
to densitize sodium channels
39
MOA of Phenytoin like drugs
to desensitize sodium channels
40
MOA of Succinimides
suppress calcium influx
41
MOA of Dopaminergic drugs
Increases biosynthesis of dopamine within nerve terminals
42
MOA of Dopaminergic Adjunct Agents
Cause dopamine release from nerve terminals
43
MOA of Anticholinergics
block acetylcholine; inhibit overactivity in brain
44
MOA of ACHE Inhibitors
to prevent breakdown of acetylcholine; enhance transmission in neurons
45
MOA of diazepam (Valium),
changing the action of GABA
46
MOA of Penobarbital (Luminal)
changing the action of GABA
47
MOA of phenytoin (Dilantin),
to densitize sodium channels
48
MOA of Fosphenytoin (Cerebyx)
to densitize sodium channels
49
MOA of Valproic acid (Depakene, Depakote)
to desensitize sodium channels
50
MOA of ethosuximide (Zarontin)
suppress calcium influx
51
MOA of levodopa (Larodopa),
Increases biosynthesis of dopamine within nerve terminals
52
MOA of Amantadine (Symmetrel)
Cause dopamine release from nerve terminals
53
MOA of Ropinirole (Requip)
Activate dopamine receptors (dopamine agonists)
54
MOA of benztropine mesylate (Cogentin)
block acetylcholine; inhibit overactivity in brain
55
MOA of donepezil hydrochloride (Aricept)
to prevent breakdown of acetylcholine; enhance transmission in neurons
56
The drug categories that work by desensitizing sodium channels are:
Hydantoins (Phenytoin) , Phenytoin-like drugs,
57
Examples of Benzodiazepines
diazepam (Valium), clonazepam (Klonopin) Lorazepam (Ativan) Clorazepate (Tranxene)
58
Examples of Barbituates
Penobarbital (Luminal) Amobarbital (Amytal) Secobarbital (Seconal) Pentobarbital (Nembutal)
59
Examples of Hydantoins
phenytoin (Dilantin), Fosphenytoin (Cerebyx)
60
Examples of Phenytoin like drugs
Valproic acid (Depakene, Depakote) Tegretol)
61
Examples of Succinimides
ethosuximide (Zarontin)
62
Examples of Dopaminergic drugs
levodopa (Larodopa), levodopa and carbidopa (Sinemet)
63
Examples of Dopaminergic Adjunct Agents
Amantadine (Symmetrel)
64
Examples of Anticholinergics
``` benztropine mesylate (Cogentin) Triexyphenidyl hydrochloride (Artane) ```
65
Examples of Immunomodulators
Interferon Beta | Glatiramer acetate
66
Examples of ACHE Inhibitors
donepezil hydrochloride (Aricept)
67
ACHE Inhibitors are used to treat
Alzheimers Disease
68
Immunomodulators are used to treat
Multiple Sclerosis (MS)
69
the drug Levodopa is more effictive when combined with the drug
carbidopa... (the drug Sinemet is Levodopa and Carbidopa combined for that reason.)
70
The Phenytoin-like drug Tegretol is used to treat _____.
Tonic-Clonic and Partial seizures.
71
Phenytoin-like drugs are better than Phenytoin because:
They have lesser side effects (newer... less cognitive effects... less sleepy.) Side effects are mostly GI.
72
Phenytoin-like drugs are used for what type of seizure?
Absence seizures
73
Hydantoins (including phenytoin) are used for what type of seizures?
all types except Absence seizures
74
If you have an overdose of Benzodiazepines, give ______.
flumazenil (Romazicon)
75
A major side effect of Benzodizazepines, Barbitrates, Hydantoins, is
severe respiratory depression
76
Nursing Implications of Benzodiazepines
Avoid alcohol, OTC drugs, and herbal medications Avoid nicotine Avoid driving and hazardous activities Rebound seizures if discontinued abruptly Take with food Drug often used illegally
77
laryngospasm is a side effect of what type of drug?
Barbituate
78
True or False: toxicity to Benzodiazepines leads to Stevens-Johnson syndrome.
False. An adverse effect of BARBITUATES is Steven-Johnsons Syndrome.
79
True or False. Hydantoin can be mixed with other IV fluids, as long as it they are clear.
False. It's rarely IV compatible. Needs it's only Normal Saline IV.
80
True or False. Benzodiazepines are used as a maintenance drug for epileptic seizures.
False. They are used DURING Tonic-Clinic Seizures.
81
Side Effects Barbituates
``` Somnolence, Agranulosis, Stevens-Johnson syndrome CNS depression (respiratory depression) dependence, drowsiness, vitamin deficiencies, laryngospasm ```
82
Side effect Hydantoins
CNS depression, gingival hyperplasia, skin rash, cardiac dysrhythmias, and hypotension
83
Nursing Implications Hydantoins
Monitor serum-drug levels Monitor for signs of toxicity Monitor for blood dyscrasias and bleeding disorders Monitor liver and kidney function Fatal hepatotoxicity can occur Patients with hypersensitivity to hydantoin products should be cautious. Rash, seizures due to hypoglycemia, sinus bradycardia, and heart block
84
Nursing Implications - Phenytoin like drugs
Monitor serum-drug levels Monitor for signs of toxicity Monitor for blood dyscrasias and bleeding disorders Monitor liver and kidney function Fatal hepatotoxicity can occur Patients with hypersensitivity to hydantoin products should be cautious. Rash, seizures due to hypoglycemia, sinus bradycardia, and heart block
85
Side Effects of Phenytoin like drugs
limited CNS depression, visual disturbances, ataxia, vertigo, headache gastrointestinal effects, hepatotoxicity, pancreatitis
86
Side effects of Succinimides
``` Drowsiness, headache, fatigue, dizziness Depression or euphoria Nausea, vomiting, weight loss Abdominal pain Life threatening reactions: Severe mental depression with suicide intent Stevens-Johnson syndrome Very rare but serious side effects: systemic lupus erythematosis, leukopenia, aplastic anemia, Stevens-Johnson syndrome Blood dyscrasias ```
87
Nursing Implications for Succinimides
Do not abruptly withdraw medication Use with caution with antiseizure medications, phenothiazines, and antidepressants Patient teaching: • Immediately report mood changes or suicidal thoughts • Avoid driving and hazardous activities • Do not suddenly stop taking • Take with food • Report symptoms of fever or sore throat • Report weight loss and anorexia
88
True or False. Pts should take Succinimides on an empty stomach to avoid side effects.
False. Take with food.
89
What drugs do you measure the serum levels?
Phenytoin (Hydantoins) and Phenytoin-like drugs
90
Side effects of Dopaminergic Drugs
dizziness, light-headedness, sleep dysfunction, fatigue, nausea, vomiting, constipation, orthostatic hypertension, dystonia, dyskinesia
91
Side effects of Anti-cholinergics
dry mouth, blurred vision, photophobia, urinary retention, constipation, tachycardia, glaucoma paralytic ileus, cardiovascular collapse
92
Paralytic ileux and cardiovasucalr collapse are side effects of what type of drug?
anticholinergics
93
side effects of immunomodulators
flushing, chest pain, weakness, infection, pain, nausea, joint pain, anxiety, muscle stiffness
94
side effects of ACHE Inhibitors
nausea/vomiting, dizziness and headache, bronchoconstriction, liver injury (tacrine(Cognex))