Central Nervous System Flashcards

1
Q

Describe the meninges of the CNS

A
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2
Q

Describe the blood brain barrier

A

Highly selective semipermeable border (endothelial cells) that prevents solutes
in the circulating blood from non-selectively crossing into the CSF

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3
Q

What is the hindbrain also known as

A

rhombencephalon

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4
Q

What are the brain and spinal cord enclosed in

A

In bony tissue

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5
Q

Name the regions of the hindbrain

A

-pons
-medulla oblongata
-cerebellum

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6
Q

Describe the medulla oblongata

A

Connection to (and nuclei of) 7th to 12th cranial nerves
Contains the cardiovascular and respiratory centres
Contains ascending and descending tracts

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7
Q

Describe the autonomic functions of the medulla

A

Heart rate and blood pressure
Breathing
Digestion
Swallowing
Sneezing
Conduction pathway for nerve tracts
Sensory nuclei

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8
Q

Role of the medulla in adjusting blood pressure

A
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9
Q

Role of medulla in adjusting breathing rate

A
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10
Q

Explain the importance of the medulla

A

Houses the spinal nucleus of the trigeminal nerve - plays a major role in the processing of sensory information from the mouth and face
extremely important in the processing of inputs related to pain and temperature from the oro-facial region
Acts as a conduction pathway for all nerve tracts passing from the spinal cord into the higher levels of the brain

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11
Q

What happens to the medulla under pressure

A

If anything causes accumulation of fluid within the cranial cavity, the intracranial pressure is raised.

As the cranial cavity is closed, the medulla is displaced downwards into the spinal canal of the cervical vertebrae and is compressed - “Coning”.

The cardiovascular and respiratory centres are compromised – this is LIFE THREATENING

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12
Q

Describe what the pons contains

A

ascending and descending tracts
The nuclei of the 5th (trigeminal – main sensory nucleus),
6th (abducent) cranial nerves and vestibular nuclei
Nuclei that connect motor pathways to the cerebellum

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13
Q

Functions of the pons

A

Assists in controlling autonomic functions
Relays sensory information between the cerebrum and cerebellum
Arousal
Sleep

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14
Q

Cross-section of the pons

A
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15
Q

What the role of the cerebellum

A

Coordinates movement

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16
Q

What happens if the cerebellum is diseased or damaged

A

motor movement becomes inaccurate (cerebellar ataxia)

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17
Q

What are signs of cerebellar ataxia

A

Signs include nystagmus (uncontrolled eye movement), dysarthria and wide-based staggering gait

18
Q

What are the 3 subdivisions of the cerebellum

A

Spinocerebellum
Cerebrocerebellum
Vestibulocerebellum

19
Q

Describe the vestibulocerebellum

A

The oldest part of the cerebellum in evolutionary terms
Participates in balance and spatial orientation
Primary connections are with the vestibular nuclei (nucleus of 8th cranial nerve)
Damage to this region causes disorders of balance and gait.

20
Q

Describe the spinocerebellum

A

Functions to fine-tune body and limb movements
It receives proprioceptive inputs from muscles and joints from the dorsal columns of the spinal cord and the trigeminal nerve
Input from the visual and auditory systems
It sends outputs to both the cerebral cortex and brainstem
Provides fine control of descending motor systems

21
Q

Describe the cerebrocerebellum

A

This is the largest functional division of the human cerebellum
Receives input from the cerebral cortex and sends output to the thalamus (in turn connected to motor areas of the of the cerebral cortex)
It is involved in the planning and timing of movements and also plays a role in cognitive functions.

22
Q

What is the midbrain also known as

A

Mesencesphalon

23
Q

Describe the midbrain

A

The midbrain is small

Posteriorly it has small bumps – the colliculi

Anteriorly the cerebral peduncles connect the hindbrain and spinal cord to the cerebrum

24
Q

Which cranial nerves arise from the midbrain

A

3rd and 4th cranial nerves
-Oculomotor and trochlear nerves

25
Q

Functions of the midbrain

A

Body movement
Controlling responses to sight
Eye movement
Pupil dilation
Hearing

26
Q

Describe the appearance of the superior and inferior colliculi and overall function of both

A

Appearance:
These appear as distinct bumps on the posterior surface of the midbrain, superior colliculi positioned rostrally

Overall function:
Integrate inputs to localize the source of various sounds and identify them as coming from a specific direction; can initiate head and body turning to orientate towards sound sources

27
Q

Describe the function of the superior colliculi

A

The superior colliculi receive input from the retina and vision-related areas of the cortex; they are involved in visual processing, in particular in the control of eye movements

28
Q

describe the function of the inferior colliculi

A

The inferior colliculi receive input from brainstem auditory nuclei and the auditory cortex

29
Q

Name the two important pairs of nuclei in the anterior part of the midbrain

A

The red nuclei – where information from the cerebellum joins motor pathways

The substantia nigra
(part of a wider system)

30
Q

Describe the function of the substantia nigra

A

uses dopamine as a neurotransmitter and
inhibits unwanted movement
amplifies desired movement

31
Q

Describe Parkinson’s disease

A

In the neurodegenerative disease, Parkinson’s Disease, dopamine is deficient so these effects do not occur producing

tremor at rest (= unwanted movement)
poverty of movement (= no amplifying of movement)

32
Q

What is the forebrain also known as

A

prosencephalon

33
Q

Name the subdivisions of the forebrain

A

Telencephalon:
Cerebrum (pair of large cerebral hemispheres)
Cerebral cortex
Basal ganglia

Diencephalon:
A group of structures deep within the cerebrum including: thalamus, hypothlamus

34
Q

Diagram of the forebrain, name the 4 lobes

A

Frontal lobe
Temporal lobe
Parietal lobe
Occipital lobe

35
Q

Diagram of the forebrain, what features allow division between the lobes

A

Central sulcus
Lateral fissure

36
Q

How many layers does the cerebral cortex have

A

Divided into 6 layers
Thickness of layers correlates with function

37
Q

Describe the different areas of the forebrain

A

Primary areas:
deal with a specific function.

Secondary areas:
integrate information from several sources and allows us to interpret signals.

Association areas:
control higher functions such as mood, personality and complex behaviour.

38
Q

Describe the sensory and motor areas

A

Are both somatotopic (provide a map of the body)

39
Q

What are the functions of the left hemisphere

A

Speech
Writing
Calculation
Language comprehension
Analytic thought processes

Language areas are in the left hemisphere in c 90% of the population

40
Q

What are the functions of the right hemisphere

A

Spatial relationships
Conceptual non verbal ideas
General thought processes