Cellular Junctions Flashcards
” Spot-weld like” / macula adherens attaches cells of the same type
Desmosomes
Attaches cells of the same type
Hemidesmosomes
Seen between epidermis and between cardiac muscle cells
Desmosomes
Seen between epidermal cells and basement membrane,
Also found between functional epithelium and tooth surface
Hemidesmosomes
Destruction of the epidermal desmosomes
Pemphigus vulgaris
Histological features of pemphigus vulgaris
Nikolsky sign
Separation of the epithelial cells
Acantholysis
Sloughing off of the skin; rub off of tissues
Nikolsky sign
Other epidermal diseases associate with nikolsky sign
- Toxic epidermal necrolysis
- Steven jhonsons
- Staphylococcal scalded skin syndrome ( SSSs)
Epidermal disease associated with hemidesmosomes
Bullous Pemphigoid
Histological features of hemidesmosomes
Subepidermal non-acantholytic blisters
Seen in cardiac muscle cells and epidermis
Desmosomes
Seen in epidermal cells and basement membrane
Hemidesmosomes
Seen in nerve cell and cardiac muscle cells
Gap junctions
“Zona occludens”
Tight junctions
Skin
Adherens junction
Formed by claudins, occludins
Tight junctions
Heart
Gap junctions
In infected cells: it sends cytokines to neighboring cells triggering apoptosis preventing infectious spread ( bystander effect )
Gap junctions
In tight junctions,——— are the proteins that hold cells tightly together
Claudins
——- are channels between cell which allow for transport of substances including ions and water
Gap junction
Are formed bygroups of proteins that anchor cells together side by side. Connecting the actin skeletons of each
Adherens junction
Are cell junctions that keep adjacent epithelial cells together using proteins that extend across the membrane and to the intermediate filaments within the cells
Desmosomes
Are connections between cells that form a watertight seal between cells
Tight junctions
Gap junctions are formed by membrane protein called
Connexins
Are proteins that attach the actin cytoskeletons or adjacent cells to one another
Cadherins
