Cellular immunity and The Complement System

Question 1

(cellular immunity) is

Answer 1

It is an immune response that involves the activation of antigen-specific cytotoxic T-lymphocytes, macrophages, natural killer cells (NK) and the release of various cytokines in response to an antigen

Question 2

Function of CMI is to

Answer 2

1- Detect and eliminate cells as intracellular pathogens
2- Recognize and eliminate cells as tumor cells)
3- stimulate cells to secrete a variety of cytokines

Question 3

MHC

Answer 3

chromosome no.6
called transplantation antigens
Histo- tissue ,compatibility
Studies of graft rejection or acceptance
First detected on leukocytes
Function-to display peptides for recognition by T-lymphocytes
n Killing infected cells or activating phagocytes or B-lymphocytes
that have ingested protein antigens

Question 4

The MHC is referred to as

Answer 4

Human leukocyte antigens)

Question 5

MHC molecules are the most_____products present
in the body

Answer 5

polymorphic

Question 6

The Major Histocompatibility Complex (MHC) is

Answer 6

is a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and “antigen presentation

Question 7

† The MHC molecules control the immune response through

Answer 7

recognition of “self” and “non-self”

Question 8

The complement system is part of the ______

Answer 8

innate immune system

Question 9

complement system naming

Answer 9

because it was first identified as a heat-labile component of serum that “complemented” antibodies in the killing of
bacteria

Question 10

the complement system is

Answer 10

It is the activity of blood serum that complete the action of antibodies

Question 11

Complement proteins normally circulate as _____

Answer 11

inactive precursors (pro-proteins, proenzymes, zymogens )

Question 12

Activation of complement

Answer 12

(removes an inhibitory fragment and exposes the active site)

Question 13

The product of complement

Answer 13

activation become covalently
attached to microbial cell surfaces or to antibodies
bound to microbes

Question 14

Complement activation is ________ by regulatory proteins
that are present on

Answer 14

inhibited
normal host cells and absent from microbes

Question 15

Complement proteins are generally synthesized by

Answer 15

liver hepatocytes, blood monocytes, tissue
macrophages, and epithelial cells of the genitourinal
tract and gastrointestinal tract

Question 16

The complement components

Answer 16

Classical: C1, C4, C2, C3 (Ca2+
; Mg2+
)
Lectin: MBL, MASP-1&-2, C4, C2, C3 (Mg2+
)
Alternative: B, D, C3 (Mg2+
)
Terminal: C5, C6, C7, C8, C9

Question 17

The Functions of Complement

Answer 17

1-Lysis
2-opsonization
3-Immune clearance

Question 18

Lysis

Answer 18

of cells, bacteria, and viruses – the major effector of the
humoral branch of the immune system.

Question 19

. Opsonization,

Answer 19

which promotes phagocytosis of particulate Ags

Question 20

Immune clearance,

Answer 20

which removes immune complexes from the
circulation and deposits them in the spleen and liver.