cellular control Flashcards
the proteins that control the development are coded for by genes called…
hox genes
how many hox genes are needed to code for the anterior and posterior body plan?
two
what are the regions called in hox genes
homeobox sequences
homeobox sequences are ‘highly conserved’, what does this mean?
sequences change very little during the evolution of different organisms that possess these homeobox sequences.
homeobox sequences code for a part of a protein called…
homeodomain
how does homeodomain control the development of the body plan?
homeodomain binds to specific sites on DNA, enabling the protein to work as a transcription factor.
It can bind to DNA at the start of developmental genes, either activating or repressing transcription - so in this way, it alters the production of proteins involved in the development of body plan.
what is apoptosis
programmed cell death
once apoptosis is triggered, how is the cell broken down? (3 step process)
- enzymes in cell break down proteins and DNA
- it begins to shrink and break into fragments
- cell fragments are engulfed by pathogen and digested.
by what two processes creates the bulk of body parts which is refined by apoptosis, by removing unwanted structures?
mitosis and differentiation
how to genes control apoptosis and mitosis?
genes can be switched on and off in cells which means some cells die, or are reproduced in order to create correct body plan.
describe an example of how external stimuli can regulate gene expression/apoptosis
Stress/lack of nutrient/attack of pathogen - can trigger gene expression that prevents cells from undergoing mitosis.
describe an example of how internal stimuli can regulate gene expression/apoptosis
DNA damage - if detected in cell cycle, this can result in expression of genes which cause cycle to be paused, and trigger apoptosis.
substitution
one or more bases are swapped for another
deletion
one or more bases are removed
insertion
one or more bases are added