Cells/Soluble Mediaters of the IS Flashcards
What are the primary Phagocytic Cells?
Polymorphonuclear Neutrophils (PMN)
Mononuclear Monocytes/Macrophages
What are the steps involved in Phagocytosis?
Chemotaxis
Adherence
Engulfment
Digestion
Subsequent Phagocytic Activity
What do lymphocytes represent?
The only immunologically specific cellular components of the IS
Adaptive component
What are the secondary Lymphoid Tissues?
Lymph Nodes
Spleen
GALT
What are T Lymphocytes involved in?
Cellular Immune Response
Antibody Reactions
What are the functions of plasma cells?
The synthesis and excretion of immunoglobulins
What can B and T cells mature into?
Effector Cells
Functional Units
What are the cell consequences associated with complement?
Cytolysis
Hemolysis
Opsonization
What are the two biological functions of the complement system?
Cell lysis by the MAC Attack
Effect of Proteolytic fragments
What can cause increased levels of complement?
Inflammatory conditions
Trauma
Acute illness (Heart Attack)
What are causes of decreased levels of complement?
Recently activated in excess
Currently being consumed
Genetic defect
How do we most frequently evaluate complement?
Serum/Plasma assay
Assessed by Nephelometry
What are the Acute phase reactants?
C-reactive Proteins (CRP)
Inflammatory Mediators
Fibrinogen
Transport Proteins
What is a stronger predictor of cardiovascular events than LDL cholesterol?
CRP Assessment
What is highly valuable in monitoring therapy and disease in CRP assessment?
Rheumatoid Arthritis
Bacterial Infections
Rheumatic Fever
Chron’s Disease
Myocardial Infection
What are two other methods we can use to detect inflammation?
Total WBC Count
Erythrocyte Sedimentation Rate (ESR)
