Cells of the nervous system Flashcards

1
Q

What are the functions of the neuron

A

Generation and conduction of electrical signals

Communication with one another via synapse

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2
Q

What cells are neurons supported by

A

Neuroglia

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3
Q

What contributes to the large diversity in neurons

A

Differences in number and shape of their processes

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4
Q

What factors contribute to CNS conditions

A

Size, location, function and metabolic activity

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5
Q

What are the ultrastructural features of neurons

A
Large nucleus
Abundant RER
Free ribosomes
Well developed golgi
Abundant mitochondria
Highly organised cytoskeleton
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6
Q

What are dendrites

A

Extensions that act as a major area of incoming information e.g. sensory neurons.

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7
Q

What is the significance of the highly branched nature of dendrites

A

Greatly increases surface area

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8
Q

How many axons usually are on a cell

A

one

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9
Q

Describe the structure of the axon

A

Emerges at the axon hillock and conducts impulses away from the cell body

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10
Q

Give a difference between axons and dendrites

A

Axons may branch but they stay the same diameter, while dendrite branches decrease in diameter

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11
Q

Which cytoskeleton elements are most prominent in axons

A

micro-tubules and neurofilaments

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12
Q

What are the domains of axon

A

Node, paranode and junta para-node

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13
Q

What is the terminal arbor

A

The area where axons branch extensively close to the target to form synaptic terminals

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14
Q

What are the two types of axon terminals

A

Boutons and varicosities

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15
Q

What is the difference between the two types of terminal

A
boutons = swelling at the end
Varicosities = multiple swellings along the axon e.g. in smooth muscle
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16
Q

Why are synapse cells abundant in mitochondria

A

Needed for ion pumping and synaptic transmission (45%)

17
Q

What are the synaptic cells sensitive to

A

Oxygen deprivation

18
Q

What is neuronal integration

A

Competing inputs are integrated in the postsynaptic neurone

19
Q

What are the types of synapse

A

Axo-dendritic (excitatory)
Axo-somatic (inhibitory)
Ax-axonic (modulatory)

20
Q

What are the cytoskeletal elements of neurons and what are their functions

A

Neurofilaments - determining axon caliber

Micro-tubules - very abundant

21
Q

What is fast axonal transport

A

Transport of membrane associated materials as vesicles are moved down the axon with associated motors

22
Q

What are the morphological subtypes

A

pseudounipolar
Bipolar
Golgi type I multipolar
Golgi type II multipolar

23
Q

Describe pseudo unipolar cells

A

Sensory neurons have 2 fused processes

24
Q

Give an example of a bipolar cells

A

retinal bipolar cells

25
Q

Describe golgi type I multipolar neurons

A
Highly branched dendritic trees
Axons extend long distances
Pyramidal cells of the cerbral cortex
Purkinje cells of the cerebellum 
Anterior horn cells of the spinal cord
Retinal ganglion cells
Most vulnerable to degeneration
26
Q

Describe golgi type II multipolar neurons

A

Short axons
Axons terminate quite close to the cell body of origin
Stellate cells of the cerebral cortex and cerebellum

27
Q

Give an example of golgi type II mutipolar

A

Cerebral cortex

28
Q

What are the functional subtypes

A

Sensory, motor and interneurons

29
Q

What is the role of interneurons

A

modification, coordination, integration, facilitation and inhibition of sensory inpu

30
Q

What are oligodendroglia

A

Cells that produce and maintain myelin sheaths. They have very few other processes

31
Q

What are the ultrastructural features of oligodendroglia

A

Prominent ER and Golgi and small spherical nuclei

32
Q

What is myelin

A

A lipid rich insulating membrane that wraps many times around the axon, giving up to as many 50 lamellae

33
Q

Give examples of myelin disease states

A

Multiple sclerosis

Adrenoleucodystrophy

34
Q

Where do the microglia derive from

A

The bone marrow

35
Q

What are the functions the microglia

A
Involved in immune surveillance
Presentation of antigens
First cells to react to infection or damage
Tissue modelling
Synaptic stripping
36
Q

What are the functions of Schwann cells

A

Myelin producing cells of the peripheral nervous system. Each cell makes one myelin sheath