Cells of IS Part 2

Question 1

T-Lymphocytes produce in?

Answer 1

Bone marrow

Question 2

T-Lymphocytes gets matured in?

Answer 2

Thymus

Question 3

T of T-Lymphocytes comes from?

Answer 3

Thymus

Question 4

T cell recptor (TCR) is heterodimer of?

Answer 4

alpha and Beta

Question 5

Molecular Marker of T-Lymphocytes?

Answer 5

CD 3 and 5

Question 6

T-Lymphocytes can recognise the Ag by?

Answer 6

help of CDR

Question 7

Cytosolic domain of alpha and beta is short, it require what for signal transduction?

Answer 7

CD3

Question 8

TCR are either

Answer 8

alpha - beta

OR

Gamma-delta

Question 9

alpha - beta TCR

Answer 9

Present on Blood

Recognise Protein Ag

95% concentration

Question 10

Gamma-delta TCR

Answer 10

Present on Tissue

Recognise Lipo-polysachharide Ag

5% concentration

Question 11

On basis of cell surface molecule, T-Cells are divided into ?

Answer 11

CD4

and CD8

Question 12

CD4

Answer 12

Helper T-cell (TH)
MHC II
Population is double of Tc
alpha - beta TCR

Question 13

CD8

Answer 13

Cytotoxic T-cell (Tc)
MHC I
Half in population of TH
alpha - beta TCR

Question 14

Nature of Ag for Cytotoxic T-cell

Answer 14

processed Ag (Viral/ Intracellular Ag)
With MHC I

Question 15

How Tc-cell gets activated?

Answer 15

CD8 binds with MHC I presenting Ag

CD8 gives signal to Tc and Tc gets activated

Tc cell releases Perforin and Granzyme b

Question 16

What does Granzyme (Serine protease) does?

Answer 16

Granzyme enters the cell and Initiate the Apoptosis which leads to cell death

Question 17

nature of Ag for TH cells

Answer 17

Processed Ag (by Endosomal-lysosomal complex)
Extracellular
CD4 Interacts with MHC II
Need Antigen presenting cells (APC)

Question 18

what happens when TC cell interacts with MHC II?

Answer 18

They proliferate and produce MEMORY CELLS and EFFECTOR T-CELLS

Question 19

EFFECTOR T-CELLS Produce?

Answer 19

Cytokines

InterleukinsIFN-Y and

TNF-alpha

Question 20

TH1 produces?

Answer 20

Pro-inflammatory Cytokines

IL2

IFN-Y and

TNF-alpha

Question 21

TH2 produces?

Answer 21

Anti-inflammatory Cytokines

IL: 4,5,6,8,10

Question 22

Shared Cytokines between TH1 and TH2 are?

Answer 22

IL-3

GM-CSF

Question 23

Marker of TH1?

Answer 23

IFN-Y

Question 24

Marker of TH2?

Answer 24

IL-4

Question 25

IL-2 is also known as?

Answer 25

Proleukin and T-cell growth Factor

Question 26

4 Functions of IL-2?

Answer 26

1. Proliferate TH1 (Autocrine behaviour) that's why its called T-cell GF 2. Activate Tc 3. Promote production of Regulatory T-Cells (By Binding to Naive T-Cells)

Question 27

What does T-regulatory Cells does?

Answer 27

Regulate other T-cells and supress to not be autoimmune

Question 28

IFN-Y and IFN-beta produce from?

Answer 28

viral infected cells

Question 29

receptors of IFN-Y PRESENT ON?

Answer 29

APC (Macrophage)

Question 30

By treating a cell with IFN-Y, we can Increase the expression of ?

Answer 30

MHC

Question 31

IFN-Y promotes class switching to ?

Answer 31

IgG

Question 32

When IFN-Y binds with AP, then?

Answer 32

Processing Increases MHC Expression Increases IL-12 gets produce

Question 33

IL-12 enhances the

Answer 33

Processing Increases MHC Expression Increases

Question 34

Il-12 binds to the?

Answer 34

APC itself and that's why (Processing Increases & MHC Expression Increases)

Question 35

IL-3 is

Answer 35

Multipotent CSF HSc's GF Mast Cell GF

Question 36

CSF is

Answer 36

Colony stimulating factor

Question 37

Receptor of IL-3 is present on?

Answer 37

Hematopoeitic Stem Cells

Question 38

When IL-3 binds with HSCs, it increases the poulation of

Answer 38

Granulocytes Megacytes Monocytes Mast cells (majorly)

Question 39

TNF-alpha increase the?

Answer 39

Vascular permeability and Vasodilation

Question 40

When Granulocutes Macrophage-CSF (GM-CSF) binds with HSCs, it increases the poulation of

Answer 40

Granulocytes and Monocytes

Question 41

TH2