Cells Flashcards

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0
Q

Functions of life carried by unicellular organisms (6)

A
Metabolism
Response
Homeostasis
Growth
Reproduction
Nutrition
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1
Q

Outline the cell theory

A
  1. Living things are made of cells
  2. Cells are the smallest units of life
  3. Cells come from pre-existing cells
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2
Q

Explain the importance of the surface area to volume ratio

A

Surface area = rate at which materials enter of leave a cell
Volume = rate a t which materials are used or produced
–> too large cells aren’t able to take essential materials and excrete wastes / loose heat quickly enough

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3
Q

Explain emergent properties

A

The whole organism is more than the sum of its parts because of complex interactions between cells (in multicellular organisms)

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4
Q

What’s differentiation of a cell?

A

Specialization of a cell - some of the genes are being activated and expressed and determine how a cell would develop
! Once a pathway of development has begun, it is usually fixed

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5
Q

Why cells differentiate?

A

Cells need different genes to develop in different ways;

each cell has a full set of genes but expresses only those it needs to follow a certain pathway of development

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6
Q

Stem cells (2)

A

1) have the capacity to self-renew by cell division - can divide and replicate
2) can differentiate along different pathways (but once committed to a given pathway, a cell can only differentiate accordingly)

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7
Q

Outline the therapeutic use of stem cells

A

Stem cells can be derived from embryos or from the placenta / umbilical cord

This process requires:

  • Chemicals to trigger differentiation
  • Surgical implantation into patient’s tissue
  • Suppression of immune system to prevent rejection
  • Monitoring new cells to ensure they don’t become cancerous

1) embryonic stem cells may successfully be implanted in patients to treat Alzheimer’s, Parkinson’s or Type I diabetes
2) Grafting new skin cells in burns victims
3) Replacing nerve cells in spinal injuries
4) people with cystic fibrosis may be treated with their own stem cells, removed and genetically engineered with the cystic fibrosis gene; when planted back, these could lead to a formation of healthy cells lining the airways of their lungs

In general if stem cells are implemented the risk of tissue rejection is eliminated

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8
Q

Parts of E. coli bacterium (9)

A

1) PILI - attachment to surfaces and other bacteria
2) FLAGELLA - movement
3) CELL WALL - protects from rupture caused by osmosis and harm by other bacteria
4) PLASMA MEMBRANE - a barrier across which all nutrients and wastes must pass
5) NUCLEOID - genetic material; single circular chromosome
6) RIBOSOME - site of protein synthesis
7) FOOD GARNULE
8) MESOSOME
9) PLASMID

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9
Q

How do prokaryotic cells differentiate?

A

By binary fission

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10
Q

Parts of liver cell (7)

A

1) ROUGH ENDOPLASMIC RETICULUM - synthesis of proteins that will be exported from the cell
2) RIBOSOME - synthesis of proteins that will remain in the cell
3) GOLGI APPARATUS - site of synthesis of chemicals required by the cell; packaged into vesicles
4) LYSOSOMES - membrane-bound vesicles, contain enzymes
5) MITOCHONDRION - carries out aerobic respiration
6) NUCLEUS - controls and directs activities of a cell, stores genetic material (strands of DNA associated with protein, stored inside a double nuclear membrane)
7) PLASMA MEMBRANE

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11
Q

State three differences between plant and animal cells

A
  1. Cell wall
    Plant cells have a cell wall (cellulose)
    Animal cells do not have a cell wall
  2. Chloroplasts
    Plant cells may have chloroplasts
    Animal cells do not have chloroplasts
  3. Large, central vacuoles
    Plant cells have a large, central vacuole
    Animal cells have small, temporary vacuoles (if any)
  4. Glucose storage
    Plant cells store glucose as starch
    Animal cells store glucose as glycogen
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12
Q

Extracellular components and their roles

A

1) Plant cell wall
- Provides support and mechanical strength (holds the plant against gravity)
- Maintains shape
- Provides a barrier against infection

2) Animal Extracellular matrix
- Formed by glycoproteins secreted by animal cells
- Provides support and anchorage for cells
- Segregates tissues from one another

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13
Q

Explain how phospholipid properties help to maintain membrane structure

A

Structure of Phospholipids:

  • polar head (hydrophilic) made of phosphate and glycerol
  • non-polar tail (hydrophobic) made of two fatty acid chains

Arrangement in Membrane:
Phospholipids spontaneously arrange in a bilayer
Hydrophobic tail regions face inwards (shielded from fluid)
Hydrophilic head regions face outwards towards the surrounding fluids

Structural Properties of Membrane

  • Bilayer held together by hydrophobic interactions (weak associations)
  • Weak associations allow for membrane fluidity / flexibility
  • Fluidity allows membrane to break and reform (exocytosis / endocytosis)
  • Hydrophilic / hydrophobic layers restrict entry of certain substances
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14
Q

Functions of membrane proteins (6)

A

Transport: Protein channels for active transport and pumps for passive transport

Receptors: Hormone recognition sites

Cell adhesion(przyczepność): Cytoskeletal attachments

Cell recognition: MHC proteins / Cell-to cell communication

Intercellular joining: Tight junctions

Enzymatic activity: Metabolic reactions

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15
Q

Diffusion

A

Passive movement of particles from a region of higher concentration to a region of lower concentration, (along the gradient);

Can occur only across membranes which are permeable to the particle and only if there’s a concentration gradient

16
Q

Osmosis

A

Passive movement of WATER MOLECULES from a region of lower solute concentration to a region of higher solute concentration across a PARTIALLY PERMEABLE membrane

17
Q

Simple diffusion

A

PASSIVE TRANSPORT - do not require ATP
Small or non-polar (lipophilic) molecules can freely diffuse across the membrane

1) the plasma membrane must be fully permeable to the solute
2) the pores in the membrane must be large enough for a solute to pass through

18
Q

Facilitated diffusion

A

PASSIVE TRANSPORT
Large or polar / charged substances cannot freely cross the membrane
They require the assistance of transport proteins (carrier proteins or channels) to passively diffuse across the membrane

A substance that is otherwise unable to diffuse across the plasma membrane does so as a result of its effect on particular molecules present in the membrane;
In the presence of that substance, globular membrane proteins form into pores large enough to allow diffusion (they close up again when the substance is no longer present)

19
Q

Active transport

A

Movement of substances across membranes using energy from ATP
can be against concentration gradient
uses protein pumps
each pump only transports specific substances so cell can control what’s absorbed and what’s expelled
Pumps work in a specific direction: the substance can only enter the pump on one side and exit only on the other

20
Q

Bulk transport

A

Movement of vesicles by process generally known as cytosis
Endocytosis = uptake
Exocytosis = export
Phagocytosis = uptake of large particles

21
Q

Explain transport between rough endoplasmic reticulum and Golgi apparatus

A
  1. Proteins are synthesized by ribosomes and enter rER
  2. Vesicles bud off from rER and carry proteins to Golgi apparatus
  3. Golgi apparatus modifies proteins
  4. Vesicles bud off from the Golgi apparatus and carry modified proteins to the plasma membrane
22
Q

Interphase

A
  • the longest phase (90% of life)
  • chromosomes (DNA) replicate in prep for cell division
  • number of mitochondria and/or chloroplasts increases

G1 - first phase of growth
S - synthesis of DNA
G2 - second phase of growth

23
Q

Phases of mitosis

A

PMAT + cytokinesis

24
Q

Prophase

A
  • longest phase
  • supercoiling of chromosomes (visible, shorter, fatter)
  • nucleoli disappear
  • centrioles migrate to poles
  • spindle micro tubules form
  • nuclear membrane disintegrates
25
Q

Metaphase

A
  • chromosomes line up in the equator
  • nuclear membrane disappears
  • spindle micro tubules attach to centromeres
26
Q

Anaphase

A
  • centromeres split up
  • sister chromosomes move to opposite poles
  • the shortest phase
27
Q

Telophase

A
  • nuclear membrane reforms

- chromosomes UNCOIL (no longer individually visible)

28
Q

Cytokinesis

A

Division of cytoplasm to form two cells

29
Q

Uses of mitosis (4)

A

1) during growth
2) during embryonic development
3) for repair of damaged tissue
4) during asexual reproduction

30
Q

Tumor formation

A

Result of uncontrolled cell division due to a change in the genes of the cell; can happen in any tissue and in any organ