Cell Wall Inhibitors

Question 0

Penicillinase Resistant Penicillins

Answer 0

Penicillinase Resitant? Yes. Duh.
Scope: Narrow
Generic Names: Nafcillin, Dicloxacillin

Question 1

Penicillin

Answer 1

Spectrum: Narrow, Gram positive

Penicillin inhibitor resistant? No. Duh.

Question 2

Aminopenicillins

Answer 2

Generic Names: Ampicillin, Amoxacillin
Penicillinase Resistant? No.
Scope: Broad. Gram negative and gram positive.

Question 3

Antipseudomonal Penicillins

Answer 3

Generic Names: Ticarcillin and Piperacillin
Penicillinase Resistant? No
Spectrum: Broad. G+ and -

Question 4

Azeotram

Answer 4

Penicillinase Resistant? yes, only one beta lactam ring

Spectrum: narrow. Gram negative rods

Question 5

Cefazolin (1st gen)

Answer 5

Spectrum: Narrow. Gram + Cocci

Blood Brain barrier? No

Question 6

Cefoxitin, Cefuroxime (2nd generation)

Answer 6

Spectrum: some gram negative, weak gram positive

BBB? No

Question 7

Ceftriaxone, Cefatoxime (3rd generation)

Answer 7

Spectrum: Broad. Sphylococci and serious gram negative

BBB? Yes!

Question 8

Cefepime

Answer 8

Spectrum: Broadest. Gram + and -, including pseudomonas

BBB? Yes

Question 9

Carbapenems: Imipenem and meropenem

Answer 9

Mechanism: Contains Beta lactam ring and binds to penicillin binding protein
Spectrum: Broad, but MRSA resistant

Question 10

Vancomycin

Answer 10

Mechanism: Binds to polypeptide chain and prevents cross linking and flipping
Scope: Narrow, gram positive, especially used for MRSA and C diff

Question 11

Bacitracin

Answer 11

Prevents dephosphorylation of protein that flips glycocalyx contents out of the cell
Spectrum: Narrow. Gram positive.

Question 12

Polymixin B

Answer 12

Bonds to phosphatidyl ethanolamine leading to holes and disruption of cell membrane
Spectrum: Narrow, mutidrug resistant gram negative

Question 13

Daptomycin

Answer 13

Binds to cell membrane and leads to depolarization and cell death
Spectrum: Narrow. MRSA treatment